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2010 | 37 | 1 | 57-67
Article title

Protective effects of melatonin against oxidative damage of macromolecules caused by selected potential carcinogens

Content
Title variants
PL
Ochronny wpływ melatoniny przed uszkodzeniem oksydacyjnym makrocząsteczek biologicznych wywołanym przez potencjalne czynniki kancerogenne
Languages of publication
EN
Abstracts
EN
Reactive oxygen species (ROS) and free radicals are essential for physiological processes in living organisms. However, an overproduction of ROS and free radicals results in enhanced oxidative stress and can lead to several diseases, cancer included. Certain carcinogens may produce ROS, which directly damage macromolecules, leading to cancer initiation. It is expected that melatonin, as a well documented antioxidant, may protect macromolecules against oxidative damage caused by certain carcinogens possessing prooxidative properties. Experimental evidence for the subject in question has been discussed in the survey.
PL
Reaktywne formy tlenu (ROS) i wolne rodniki odgrywają istotną rolę w przebiegu procesów fizjologicznych w organizmach Ŝywych. Nadmierne wytwarzanie ROS i wolnych rodników moŜe jednakŜe prowadzić do nasilenia stresu oksydacyjnego i – w efekcie – do wyindukowania wielu chorób, w tym nowotworów złośliwych. Niektóre kancerogeny mogą indukować wytwarzanie ROS, które – następnie – uszkadzają makrocząsteczki w sposób bezpośredni, wiodąc do inicjacji nowotworzenia. UwaŜa się, Ŝe melatonina, jako dobrze udokumentowana substancja antyoksydacyjna, moŜe zapobiegać uszkodzeniom oksydacyjnym makrocząsteczek wywołanym przez niektóre kancerogeny posiadające właściwości prooksydacyjne; w pracy przedstawiono dowody doświadczalne dotyczące powyŜszych efektów melatoniny.
Discipline
Year
Volume
37
Issue
1
Pages
57-67
Physical description
Contributors
  • Department of Oncological Endocrinology, Medical University of Lodz, Poland, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
  • Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Poland, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
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Document Type
paper
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-9c9b2d88-8838-42b1-8883-a4e71ac67fac
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