Current view about basophils and their significance in the allergic immune response

• Authors: Magdalena Kujawiak , Janina Grzegorczyk

Title variants

PL

Aktualna wiedza o bazofilach i ich roli w reakcjach alergicznych

• Languages of publication: EN

Abstracts

EN

Basophils are one of major effector cells participating in the immune response despite the fact that they constitute a small population of peripheral blood leukocytes. They are activated by cross-linking of an antigen with IgE through FcεRI and then they release a wide range of mediators, implicated in the pathogenesis of allergic diseases. Basophils are essential cells in IgG-mediated systemic anaphylaxis and currently are considered as antigen-presenting cells. This review summarizes recent studies and reports on basophils, their origin and role in the immune response, and their participation in diseases. Widening of our knowledge about basophils can help us to understand better the mechanisms of the complex processes in which those cells are involved.

PL

Bazofile to jedne z najistotniejszych komórek uczestniczących w odpowiedzi immunologicznej, mimo iż stanowią niewielką populację we krwi obwodowej. Ulegają aktywacji w krzyżowej reakcji wiązania antygenu przez przeciwciało IgE do receptora FcεRI. Uwalniają szerokie spektrum mediatorów, co przekłada się na implikacje w patogenezie chorób alergicznych. Odgrywają także znaczącą rolę w uogólnionych reakcjach anafilaktycznych z udziałem przeciwciał IgG, a także jako komórki prezentujące antygen. Ta praca jest podsumowaniem aktualnej wiedzy o bazofilach, ich pochodzeniu i roli w reakcjach alergicznych oraz znaczeniu w jednostkach chorobowych. Poszerzanie wiedzy z tego zakresu jest niezbędne do lepszego zrozumieniu mechanizmów skomplikowanych procesów, w których bazofile uczestniczą.

Keywords

EN

Th1/Th2 response; cell differentiation; cytokines; cytokiny; late-phase reaction (LPR); odpowiedź Th1/Th2; reakcja późnej fazy (LPR); releasability; różnicowanie komórek; zjawisko „basophilreleasability”

Discipline

• MEDICINE: MEDICINE

• Publisher: Łódzkie Towarzystwo Naukowe
• Journal: Folia Medica Lodziensia
• Year: 2011
• Volume: 38
• Issue: 2
• Pages: 177-200

Contributors

author

Magdalena Kujawiak

• Department of Laboratory Medical Immunology, Medical University of Lodz

author

Janina Grzegorczyk

• Department of Laboratory Medical Immunology, Faculty of Pharmacy, Medical University of Lodz, Poland

References

• Wedemeyer J, Galli SJ. Mast cells and basophils in acquired immunity. Br Med Bull. 2000; 56: 936-955.
• Galli SJ. Mast cells and basophils. Curr Opin Hematol. 2000; 7: 32-39.
• Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2006; 117: 450-456.
• Arock M, Schneider E, Boissan M, Tricottet V, Dy M. Differentiation of human basophils: an overview of recent advances and pending questions. J Leukoc Biol. 2002; 71: 557-564.
• Falcone FH, Haas H, Gibbs BF. The human basophil: a new appreciation of its role in immune responses. Blood. 2000; 96: 4028-4038.
• Bochner BS. Systemic activation of basophils and eosinophils: markers and consequences. J Allergy Clin Immunol. 2000; 106: 292-302.
• Hida S, Tadachi M, Saito T, Taki S. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood. 2005; 106: 2011 2017.
• Triggiani M, Marone G. Basophil's secrets revealed by flow cytometry. Allergy. 2006; 61: 1025-1027.
• Bischoff SC, Brunner T, De Weck AL, Dahinden CA. Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists. J Exp Med. 1990; 172: 1577-1582.
• Buckley MG, McEuen AR, Walls AF, The return of the basophil. Clin Exp Allergy. 2002; 32: 8-10.
• Bodger MP, Mounsey GL, Nelson J, Fitzgerald PH. A monoclonal antibody reacting with human basophils. Blood. 1987; 69: 1414-1418.
• Bühring HJ, Simmons PJ, Pudney M, Müller R, Jarrossay D, van Agthoven A et al. The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors. Blood. 1999; 94: 2343-2356.
• Min B. Basophils: what they 'can do' versus what they 'actually do'. Nat Immunol. 2008; 9: 1333-1339.
• Falcone FH, Zillikens D, Gibbs BF. The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity. Exp Dermatol. 2006; 15: 855-864.
• Kepley CL, Craig SS, Schwartz LB. Identification and partial characterization of a unique marker for human basophils. J Immunol. 1995; 154: 6548-6555.
• Charlesworth EN. The role of basophils and mast cells in acute and late reactions in the skin. Allergy. 1997; 52: 31-43.
• Agis H, Krauth MT, Böhm A, Mosberger I, Müllauer L, Simonitsch-Klupp I et al. Identification of basogranulin (BB1) as a novel immunohistochemical marker of basophils in normal bone marrow and patients with myeloproliferative disorders. Am J Clin Pathol. 2006; 125: 273-281.
• KleinJan A, McEuen AR, Dijkstra MD, Buckley MG, Walls AF, Fokkens WJ. Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation. J Allergy Clin Immunol. 2000; 106: 677-686.
• Kinet JP. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu RevImmunol. 1999; 17: 931-972.
• Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008; 9: 310-318.
• MacGlashan D Jr, McKenzie-White J, Chichester K, Bochner BS, Davis FM, Schroeder JT et al. In vitro regulation of FcepsilonRIalpha expression on human basophils by IgE antibody. Blood. 1998; 91: 1633-1643.
• Galli SJ, Lantz CS. Allergy. W: Fundamental Immunology, Paul WE (red.), Philadelphia: Lippincott Williams&Wilkins, 1999: 1137-1184.
• Brunner T, Heusser CH, Dahinden CA, Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J Exp Med. 1993; 177: 605-611.
• Florian S, Sonneck K, Czerny M, Hennersdorf F, Hauswirth AW, Bühring HJ et al. Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies. Allergy. 2006; 61: 1054-1062.
• Samorapoompichit P, Kiener HP, Schernthaner GH, Jordan JH, Agis H, Wimazal F et al. Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms. Blood. 2001; 98: 2580 2583.
• Welker P, Grabbe J, Henz BM. Differential expression of mast cell characteristics in human myeloid cell lines. Exp Dermatol. 2004; 13: 535-542.
• Li L, Li Y, Reddel SW, Cherrian M, Friend DS, Stevens RL et al. Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients. J Immunol. 1998; 161: 5079-5086.
• Denburg JA, Silver JE, Abrams JS. Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors. Blood. 1991; 77: 1462-1468.
• Dy M, Pacilio M, Arnould A, Machavoine F, Mayeux P, Hermine O et al. Modulation of histidine decarboxylase activity and cytokine synthesis in human leukemic cell lines: relationship with basophilic and/or megakaryocytic differentiation. Exp Hematol. 1999; 27: 1295-1305.
• Falcone FH, Pritchard DI, Gibbs BF. Do basophils play a role in immunity against parasites? Trends Parasitol. 2001; 17: 126-129.
• Maruyama N, Tamura G, Aizawa T, Ohrui T, Shimura S, Shirato K et al. Accumulation of basophils and their chemotactic activity in the airways during natural airway narrowing in asthmatic individuals. Am J Respir Crit Care Med. 1994; 150: 1086-1093.
• Min B, Paul WE. Basophils and type 2 immunity. Curr Opin Hematol. 2008; 15: 59-63.
• Voehringer D. Basophils in immune responses against helminths. Microbes Infect. 2011; 13: 881-887.
• Schwartz C, Vehringer D. Basophils: important emerging players in allergic and anti-parasite responses. Bioessays. 2011; 33: 423-426.
• Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol. 2009; 10: 706-712.
• Oh K, Shen T, Le Gros G, Min B. Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood. 2007; 109: 2921-2927.
• Schroeder JT, MacGlashan DW, Lichtenstein LM. Human basophils: mediator release and cytokine production. Adv Immunol. 2001; 77: 93-122.
• Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med. 2004; 200: 507-517.
• Falcone FH, Dahinden CA, Gibbs BF, Noll T, Amon U, Hebestreit H et al. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. Eur J Immunol. 1996; 26: 1147-1155.
• Foster B, Schwartz LB, Devouassoux G, Metcalfe DD, Prussin C. Characterization of mast-cell tryptase-expressing peripheral blood cells as basophils. J Allergy Clin Immunol. 2002; 109: 287-293.
• Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol. 2009; 10: 713-720.
• Karasuyama H, Obata K, Wada T, Tsujimura Y, Mukai K. Newly appreciated roles for basophils in allergy and protective immunity. Allergy. 2011; 66: 1133 1141.
• Mukai K, Obata K, Tsujimura Y, Karasuyama H. New insights into the roles for basophils in acute and chronic allergy. Allergol Int. 2009; 58: 11-19.
• Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008; 28: 581-589.
• Finkelman FD. Anaphylaxis: lessons from mouse models. J Allergy Clin Immunol. 2007; 120: 506-515; quiz 516-517.
• Mack M, Schneider MA, Moll C, Cihak J, Brühl H, Ellwart JW et al. Identification of antigen-capturing cells as basophils. J Immunol. 2005; 174:735 741.
• Kepley CL, Cambier JC, Morel PA, Lujan D, Ortega E, Wilson BS et al. Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. J Allergy Clin Immunol. 2000; 106: 337-348.
• Sloane DE, Tedla N, Awoniyi M, Macglashan DW Jr, Borges L, Austen KF et al. Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood. 2004; 104: 2832-2839.
• Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M et al. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003; 301: 1527-1530.
• Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y et al. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007; 110: 913-920.
• Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol. 2009; 10: 697-705.
• Kay AB. Overview of 'allergy and allergic diseases: with a view to the future'. Br Med Bull. 2000; 56: 843-864.
• Schroeder JT, Kagey-Sobotka A, Lichtenstein LM. The role of the basophil in allergic inflammation. Allergy. 1995; 50: 463-472.
• Macfarlane AJ, Kon OM, Smith SJ, Zeibecoglou K, Khan LN, Barata LT et al. Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late phase allergic reactions in the lung and skin. J Allergy Clin Immunol. 2000; 105: 99-107.
• Marone G, Poto S, di Martino L, Condorelli M. Human basophil releasability. I. Age-related changes in basophil releasability. J Allergy Clin Immunol. 1986; 77: 377-383.
• Miura K, Saini SS, Gauvreau G, MacGlashan DW Jr. Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. J Immunol. 2001; 167: 2282-2291.
• Ochensberger B, Tassera L, Bifrare D, Rihs S, Dahinden CA. Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. Eur J Immunol. 1999; 29: 11-22.
• Schroeder JT, Chichester KL, Bieneman AP. Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease. J Immunol. 2009; 182: 2432-2438.
• Iikura M, Yamaguchi M, Fujisawa T, Miyamasu M, Takaishi T, Morita Y et al. Secretory IgA induces degranulation of IL-3-primed basophils. J Immunol. 1998; 161: 1510-1515.
• Kuna P, Lazarovich M, Kaplan AP. Chemokines in seasonal allergic rhinitis. J Allergy Clin Immunol. 1996; 97: 104-112.
• Heinemann A, Hartnell A, Stubbs VE, Murakami K, Soler D, LaRosa G et al. Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling. J Immunol. 2000; 165: 7224-7233.
• Lie WJ, Homburg CH, Kuijpers TW, Knol EF, Mul FP, Roos D et al. Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. Clin Exp Allergy. 2003; 33: 1125-1134.
• Abrahamsen O, Haas H, Schreiber J, Schlaak M. Differential mediator release from basophils of allergic and non-allergic asthmatic patients after stimulation with anti IgE and C5a. Clin Exp Allergy. 2001; 31: 368-378.
• Lichtenstein LM, Norman PS, Connell JT. Comparison between skin-sensitizing antibody titers and leukocyte sensitivity measurements as an index of the severity of ragweed hay fever. J Allergy. 1967; 40: 160-167.
• Crockard AD, Ennis M. Basophil histamine release tests in the diagnosis of allergy and asthma. Clin Exp Allergy. 2001; 31: 345-350.
• Kałła M, Rożniecki J, Grzegorczyk J. Ocena zależności między uwalnianiem histaminy z bazofilów pod wpływem alergenu pyłkowego i wrażliwością oskrzeli na wziewną polimyksynę B a stamen klinicznym chorych na astmę pyłkową odczulanych pollineksem. Pneumonol Pol. 1984; 52: 279-286.
• Prescott SM, Zimmerman GA, Stafforini DM, McIntyre TM. Platelet-activating factor and related lipid mediators. Annu Rev Biochem. 2000; 69: 419-445.
• Wills-Karp M. Interleukin-13 in asthma pathogenesis. Curr Allergy Asthma Rep. 2004; 4(2): 123-131.
• Tschopp CM, Spiegl N, Didichenko S, Lutmann W, Julius P, Virchow JC et al. Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood. 2006; 108: 2290-2299.
• Schleimer RP, Sterbinsky SA, Kaiser J, Bickel CA, Klunk DA, Tomioka K et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol. 1992; 148: 1086-1092.
• Tsang S, Hayashi M, Zheng X, Campbell A, Schellenberg RR. Simplified purification of human basophils. J Immunol Methods. 2000; 233:13-20.
• Li Y, Li L, Wadley R, Reddel SW, Qi JC, Archis C et al. Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood. 2001; 97: 3484-3490.
• Blom T, Nilsson G, Sundström C, Nilsson K, Hellman L. Characterization of a human basophil-like cell line (LAMA-84). Scand J Immunol. 1996; 44: 54 61.
• Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2003; 111: S486-494.
• Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005; 23: 191 202.
• Grattan CE, Dawn G, Gibbs S, Francis DM. Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity. Clin Exp Allergy. 2003; 33: 337-341.
• Lichtman MA. Basophilopenia, basophilia and mastocytosis. W: Williams Hematology, Bentler E, Lichtman MA, Coller BS, Kipps TJ (red.), 1995; 852 855.
• De Swerdt A, Van Den Keybus C, Kasran A, Cadot P, Neyens K, Coorevits L et al. Detection of basophil-activating IgG autoantibodies in chronic idiopathic urticaria by induction of CD 63. J Allergy Clin Immunol. 2005; 116: 662-667.
• Wilson DR, Irani AM, Walker SM, Jacobson MR, Mackay IS, Schwartz LB et al. Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium. Clin Exp Allergy. 2001; 31: 1705-1713.
• Kepley CL, McFeeley PJ, Oliver JM, Lipscomb MF. Immunohistochemical detection of human basophils in postmortem cases of fatal asthma. Am J Respir Crit Care Med. 2001; 164: 1053-1058.
• Falcone FH, Knol EF, Gibbs BF. The role of basophils in the pathogenesis of allergic disease. Clin Exp Allergy. 2011; 41: 939-947.
• Marone G. Asthma: recent advances. Immunol Today. 1998; 19: 5-9.

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