PL EN


Preferences help
enabled [disable] Abstract
Number of results
2018 | 108 | 195-206
Article title

Initial pro-antioxidant reactions in the patients suffering from cataract in the interactions with cadmium and lead

Content
Title variants
Languages of publication
EN
Abstracts
EN
Cataract is one of the main causes of vision loss. So far, it has been found that one of the causes of cataract formation is the accumulation of heavy metals in ocular tissues and environmental pollution. Research material consisted of blood from healthy volunteers (n = 81; Mogilno Lakeland) and those suffering from cataract (n = 90) from Ophthalmology Clinic, Bydgoszcz (2013, 2016). Samples were prepared in order to obtain plasma, which was used to analyze Fe, Cu, Zn, Mn, Pb, Cd, and Hg concentration (ICP-MS). The purpose of this study is to show the interaction of cataract with cadmium and lead during initial pro-antioxidative reactions and to study element-element interactions. To this end, we analyzed physiological mechanisms that aim to stop the destructive effects of toxic metals. We have shown that the action of zinc, copper and manganese is antioxidant. Concentration of these elements is higher (α = 0. 05, p < 0.05) in the cataract group than in the control. We found interactions Fe-Cu-Zn-Mn-Pb-Cd-Hg. Cd and Pb show a negative effect on the eye tissue and generate pathophysiological changes leading to lens opacity and influence the destabilization of pro-antioxidant reactions. Correlations of elements in the control (Cd-Zn: R = 0.240; Cd-Cu: R = 0.316) and in the sick group (Cd-Cu; R = 0.329) were significant. On the basis of our research we found that there are numerous relationships between the concentrations of chemical elements in the patients with cataracts and the controls. Significant role of antagonisms with cadmium and lead has been demonstrated; these elements contribute to the gradual development of cataract. A correlation between elements exhibiting pro-antioxidant activity in the interactions with cadmium and lead (p=0.000) can be a source of cataract changes. The differences in Cd and Pb concentration and their interactions with elements between the control and sick groups can be considered as a factor for the development of cataract.
Discipline
Year
Volume
108
Pages
195-206
Physical description
Contributors
  • University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, 1 Prof. Szafran Str., PL 65-516 Zielona Góra, Poland
  • University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, 1 Prof. Szafran Str., PL 65-516 Zielona Góra, Poland
  • Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Faculty of Medicine, University Hospital No. 1, Department of Eye Diseases, 9 M. Skłodowska-Curie Str., PL 85-092 Bydgoszcz, Poland
  • University of Technology and Life Sciences, Faculty of Animal Breeding and Biology, Department of Genetics and Animal Breeding, 28 Mazowiecka Str., PL 85-084 Bydgoszcz, Poland
  • University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, 1 Prof. Szafran Str., PL 65-516 Zielona Góra, Poland
References
  • [1] Katarzyna Kempka, Environmental determinants of pathophysiological changes in cataract, Master Thesis. University of Zielona Góra (2017).
  • [2] Neil Cambell et al. Biology. Pearson, Benjamin Cummings 8th Ed. (2008).
  • [3] Cynthia Bradford. Basic Ophthamology for Medical Students and Primary Care Residents. Publisher: American Academy of Ophthalmology (2004). ISBN-10: 1560553618
  • [4] WHO, World Health Organization. WHO laboratory manual for examination and processing of human. 5th ed., Cambridge Univ. Press, 268 pp, (2016).
  • [5] Asbell, Penny A., Ivo Dualan, Joel Mindel, Dan Brocks, Mehdi Ahmad, and Seth Epstein. 2005. Age-related cataract. The Lancet 365 (9459): 599–609.
  • [6] Thiagarajan, R., and R. Manikandan. Antioxidants and Cataract. Free Radical Research 47 (5) (2013) 337–45.
  • [7] Bartosz Grzegorz. The second face of oxygen - free radicals in nature. Polish Scientific Publishers. Warsaw (2006).
  • [8] Józef Kałużny. Anatomy. In Lens and Cataract. Urban & Partner. Wrocław (2007).
  • [9] Kabata-Pendias A., and Mukherjee A.B. Trace Elements from Soil to Human. Springer-Verlag. (2007).
  • [10] Alina Kabata-Pendias and Henryk Pendias. Trace elements in soils and plants. 3rd ed. Boca Raton, Fla: CRC Press. (2001).
  • [11] David Heisermann. Exploring Chemical Elements and Their Compounds. McGraw-Hill Companies, Incorporated. (1991).
  • [12] M. Wieloch et al., Do toxic heavy metals affect antioxidant defense mechanisms in humans?, Ecotoxicol. Environ. Saf. 78 (2012) 195–205.
  • [13] Marek Siemiński. Chrome, cobalt, manganese, nickel, copper, zinc, molybdenum, vanadium, iron. In Environmental health hazards. Polish Scientific Publishers. Warsaw (2008).
  • [14] J. W. Eichenbaum i W. Zheng. Distribution of lead and transthyretin in human eyes. J. Toxicol. Clin. Toxicol. 38 (4) (2000) 377–381.
  • [15] J. C. Erie, J. A. Butz, J. A. Good, E. A. Erie, M. F. Burritt, and J. D. Cameron. Heavy Metal Concentrations in Human Eyes. Am. J. Ophthalmol. 139 (5) (2005) 888–893.
  • [16] N. S. Haddad, S. Z. Alasadi, and H. H. Haddad, Contamination of Heavy Metals (Lead, Zinc, Magnesium and Manganese) Concentrations in Human Eyes. Am. J. Anal. Chem. 3 (7) (2012) 491–494.
  • [17] N. K. Wills et al.. Cadmium accumulation in the human retina: Effects of age, gender, and cellular toxicity. Exp. Eye Res. 86 (1) (2008) 41–51.
  • [18] H. Czeczot i M. Majewska. Cadmium-threat and health effects. Farm Pol 66 (4) (2010) 243–250.
  • [19] N. K. Wills et.al. Human retinal cadmium accumulation as a factor in the etiology of age-related macular degeneration. Exp. Eye Res. 89 (1) (2009) 79–87.
  • [20] W. Wang, D. A. Schaumberg, and S. K. Park. Cadmium and lead exposure and risk of cataract surgery in U.S. adults. Int. J. Hyg. Environ. Health, 219 (8) (2016) 850–856.
  • [21] M. Wołonciej, E. Milewska, and W. Roszkowska-Jakimiec. Trace elements as activators of antioxidant enzymes. Adv. Hyg. Exp. Med. Hig. Med. Doswiadczalnej. 70 (2016).
  • [22] [23] A. Behndig, K. Karlsson, A. G. Reaume, M.-L. Sentman, and S. L. Marklund. In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase. Free Radic. Biol. Med. 31 (6) (2001) 738–744.
  • [23] N. Shukla, J. K. Moitra, and R. C. Trivedi. Determination of lead, zinc, potassium, calcium, copper and sodium in human cataract lenses. Sci. Total Environ. 181 (2) (1996) 161–165.
  • [24] D. Celojevic et. al. Superoxide Dismutase Gene Polymorphisms in Patients with Age-related Cataract. Ophthalmic Genet. 34 (3) (2013) 140–145.
  • [25] R. J. W. Truscott. Age-related nuclear cataract—oxidation is the key. Exp. Eye Res. 80(5) (2005) 709–725.
  • [26] J. Reddan, M. Sevilla, F. Giblin, V. Padgaonkar, D. Dziedzic, and V. Leverenz. Tempol and deferoxamine protect cultured rabbit lens epithelial cells from H2O2 insult: insight into the mechanism of H2O2-induced injury. Lens Eye Toxic. Res. 9 (3–4) (1992) 385–393.
  • [27] G. Goutham et al. A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance. Biomed. Pharmacother. 86 (2017) 232–241.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-9c24b6a9-b049-4a79-b24c-7ef703c32a46
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.