STUDIES OF NORFLOXACIN ADSORPTION ON CHITOSAN

• Authors: Jan Meler , Bożena Grimling , Janusz Pluta
• Languages of publication: EN

Abstracts

EN

In clinical practice a lot of natural macromolecular compounds which operation is based on assisting weight loss are used in the obesity treatment. These measures swell in the digestive tract and form the polymer gel system, which has the ability to adsorb up to 5 times more lipids relative to its own weight. When using dietary supplements containing chitosan, sometimes it comes to illness and in the therapy other agents such as chemotherapeutics are used. The aim of our study was to determine the binding capacity of chemotherapeutic norfloxacin present in the digestive tract model by chitosans found in slimming medicines, depending on variable physico-chemical factors. Phenomenon of norrfloxacin adsorption was studied by a dynamic pharmaceutical model simulating in vitro conditions. The amount of adsorbed chemotherapeutic agent by chitosan was calculated by the difference in concentrations of study drug before and after sorption. The results of measurements of quantities bounded norfloxacin were used to calculate the average percentage of adsorbed dose. The results show that norfloxacin is adsorbed by the chitosans in the applicable pH ranges, and the binding capacity depends on the pH, viscosity and concentration of chemotherapeutics, as well as the type of chitosan and additional substances in the gastrointestinal tract. The average amount of chemotherapeutic adsorption in the system chitosan-nutrients, depending on the pH ranged from 80 to 98%. The highest number of adsorption points above pH 7. In conclusion, the addition of dietary supplement such as chitosan reduces the amount of administered uniformly chemotherapeutic and simultaneously has a large impact on the bioavailability. The observed dependence may require changes in therapeutic process.

Keywords

EN

adsorption; chitosan; norfloxacin

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2012
• Volume: 17
• Pages: 103 - 110

Contributors

author

Jan Meler

• Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw

author

Bożena Grimling

• Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw

author

Janusz Pluta

• Faculty of Pharmacy The “Silesian Piast” memorial Medical University of Wroclaw

References

• Drlica K, Zhao X “DNA gyrase, topoisomerase IV, and the 4-quinolones”. Microbiol Mol Biol Rev. 1997; 61; 377–92.
• Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N “Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group”. Antimicrob. Agents Chemother. 1992; 36; 751–6.
• Sissi C, Palumbo M “The quinolone family: from antibacterial to anticancer agents”. Curr. Med. Chem. Anticancer Agents 2003; 3; 439–50.
• A.C. Ford, S.V. Kane, K.J. Khan, Jean-Paul Achkar, N. J. Talley, J.K. Marshall and P. Moayyedi. Efficacy of 5-Aminosalicylates in Crohn’s Disease: Systematic Review and Meta-Analysis. Am J Gastroenterol 2011; 106: 617–629.
• U, Filipkowska, E. Klimiuk, S. Grabowski,E , Siedlecka, . Adsorption of reactive dyes by modified chitin from aqueous solutions Pol. J. Environ. Stud., 11, 315- 323.
• J. Meler, J. Pluta. The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical patternelof digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, pp. 131-137, 2004
• B. Grimling, J. Meler, J. Pluta.: Study of interaction of gastrointestinal agents in the presence of cytoprotective drug including bismuth W: Pierwiastki, środowisko i życie człowieka ; pod red. Kazimierza Pasternaka; Lublin : Polskie Towarzystwo Magnezologiczne, 2009; pp. 65-74.
• J. Meler, B. Grimling, J. Pluta.: Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium J. Elementol. 2010 Vol. 15 no. 1; 141-147.
• J. Meler.: Influence of different change on bioavailability of medicine chitosans antiphlogistic drugs Progress on Chemistry and Application of Chitin and Its Derivatives 2008 Vol. 13; 81-88
• J. Meler.: The effect of physicochemical factors on absorption properties of certain spasmolytics in the presence of dietary supplements containing chitosan Progress on Chemistry and Application of Chitin and Its Derivatives 2009 Vol. 14; 133-1435.

• Document Type: article