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2013 | 16 | 4 | 7-15
Article title

Environmental factors influencing the development of atherosclerosis

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Title variants
PL
Czynniki środowiskowe wpływające na rozwój miażdżycy
Languages of publication
EN
Abstracts
EN
The aim of the paper is to present an overview of recent findings on the environmental and behavioral factors influencing the development of atherosclerosis.
The authors primarily concentrated on deliberations of possibile main causes of the damage of the endothelium.
At the same time the following pathogenic mechanisms as cellular dysfunction, inflammation and coagulation disorders have been enumerated.
The links between the state of the vascular endothelium and life style have been emphasized. It is also important to note that the primary causes of the endothelial damage should be traced as originally suggested many years ago viewing such factors as anger, hostility, aggression, impulsiveness and depression but with a new approach.
The authors supplement the comments, on the environmental factors influencing the development of atherosclerosis, with basic data on family predisposition to the development of this disease. They highlight that current genetic research have not determined genes responsible
for atheroscelosis.
According to the authors the considerations and conclusions presented in this overview are important for
the educational purposes related to the most frequent disease process resulting in many diseases in medical disciplines.
PL
Celem pracy jest dokonanie przeglądu najnowszych ustaleń dotyczących czynników środowiskowych i behawioralnych biorących udział w powstawaniu i patogenezie miażdżycy. Tym samym, jakkolwiek wymieniono w niej takie mechanizmy patogenetyczne jak zaburzenia funkcji makrofagów, procesy zapalne i zaburzenia krzepnięcia, to jednak autorzy skoncentrowali się przede wszystkim na rozważeniu możliwych pierwotnych przyczyn uszkodzenia śródbłonka naczyń. Podkreślono powiązania pomiędzy jego stanem a stylem życia. Istotnym jest zwrócenie uwagi na fakt, że poszukując pierwotnych przyczyn uszkodzenia śródbłonka należy ponownie – lecz z użyciem nowego warsztatu – rozważyć rolę zaproponowanych, już wiele lat temu, czynników osobowościowych i behawioralnych, a wśród nich wrogość, agresywność, impulsywność czy depresję.
Komentarze o środowiskowych czynnikach wpływających na rozwój miażdżycy uzupełniono ponadto danymi
na temat predyspozycji rodzinnej do powstawania tego procesu chorobowego. Podkreślono, że dotychczasowe badania genetyczne nie określiły krytycznych chorobotwórczych wariantów genów, co skłoniło autorów do tymczasowego sformułowania o „braku wyznaczników dziedziczności”.
Przedstawione rozważania mają zdaniem autorów znaczenie dla uzupełnienia procesu dydaktycznego dotyczącego tego najbardziej rozpowszechnionego procesu chorobowego skutkującego licznymi jednostkami chorobowymi w wielu dyscyplinach medycznych.
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Document Type
review
Publication order reference
YADDA identifier
bwmeta1.element.psjd-996ba736-ad9a-4bc3-9277-59f964107df4
Identifiers
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