Kierunki w etiopatognezie pierwotnego zespołu Sjögrena

• Authors: Agata Sebastian , Piotr Wiland

Title variants

EN

Trends in etiopathogenesis of primary Sjögren’s syndrome

• Languages of publication: PL EN

Abstracts

PL

Pierwotny zespół Sjögrena (PZS) należy do grupy chorób autoimmunologicznych. W swoim poważnym przebiegu wiąże się ze zwiększoną śmiertelnością poprzez zajęcie narządów wewnętrznych oraz rozwój chłoniaków B komórkowych. Dla PZS charakterystyczne jest tworzenie się nacieków limfocytarnych powodujących dysfunkcję gruczołów wydzielania wewnętrznego. Podobnie jak w wielu innych chorobach autoimmunologicznych nie są znane czynniki zapoczątkowujące proces chorobowy. U chorych na PZS stwierdza się typowe nacieki limfocytarne w gruczołach ślinowych. Pomimo, że nacieki te są dobrze scharakteryzowane, nie znamy dotychczas patogenezy ich powstawania. W pracy przedstawiono podsumowanie potencjalnych grup cytokin zaangażowanych w etiopatogenezę PZS.

EN

Primary Sjögren syndrome (pSS) is a systemic autoimmune disease and can be a serious disease with excess mortality due to severe organ-specific involvements and the development of B-cell lymphoma. PSS is characterized by lymphocytic infiltration of exocrine glands, resulting in glandular dysfunction. Similarly to many other autoimmune diseases, the inciting factors that precipitate pSS are poorly understood. Patients with pSS have specific lymphocytic infiltration of salivary glands. While this infiltration is well characterized, the pathologic events that precede and cause this inflammatory cell recruitment are unknown. This review summarizes the potential cytokine families involved in the etiopathogenesis of primary pSS.

Keywords

EN

patogeneza; zespół Sjögrena

Discipline

• MEDICINE: MEDICINE

• Publisher: Oficyna Wydawnicza Mediton
• Journal: Alergia Astma Immunologia - przegląd kliniczny
• Year: 2018
• Volume: 23
• Issue: 1
• Pages: 35-39

Contributors

author

Agata Sebastian

• Klinika Reumatologii i Chorób Wewnętrznych. Uniwersytecki Szpital Kliniczny we Wrocławiu

author

Piotr Wiland

• Klinika Reumatologii i Chorób Wewnętrznych. Uniwersytecki Szpital Kliniczny we Wrocławiu

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• Document Type: article