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2012 | 2 | 4 | 255-261
Article title

Chemioterapia w guzach neuroendokrynnych układu pokarmowego (GEP-NEN)

Title variants
Chemotherapy in gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN)
Languages of publication
Nowotwory neuroendokrynne układu pokarmowego w chwili rozpoznania choroby są w stadium rozsianym u ok. 2/3 chorych. Chemioterapia z użyciem schematu cisplatyna + etopozyd pozostaje standardem w przypadku zaawansowanych postaci niskozróżnicowanych raków neuroendokrynnych (NEC G3 wg klasyfikacji WHO z 2010 r.). W przypadku dobrze zróżnicowanych nowotworów neuroendokrynnych trzustki streptozotocyna, doksorubicyna i/lub 5-Fu są uważane za chemioterapię standardową, mimo że nie ma randomizowanych badań porównujących ją z innymi terapiami. Międzynarodowe wytyczne nie rekomendują stosowania chemioterapii w rozsianych nowotworach neuroendokrynnych pochodzących ze środkowego odcinka prajelita (midgut). Chorzy ci powinni być kwalifikowani do innego typu leczenia.
Approximately two-thirds of malignant GEP-NENs are metastatic at discovery. Chemotherapy with platinum and etoposide is a standard therapy for poorly differentiated GEP-NEC. For well-differentiated pancreatic GEP-NEN association of streptozotocin/doxorubicin and/or 5-Fu is a standard. However, it requires comparison with other established therapies. International recommendations have suggested abandoning the use of classical cytotoxics in the treatment of metastatic midgut tumours in favour of more suitable options when applicable.
Physical description
  • Oddział Chemioterapii, Klinika Onkologii Centrum Onkologii􀂉 Instytut im. Marii Skłodowskiej-Curie w Warszawie
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