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2014 | 19 | 95-101
Article title

PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH THE ADDITION OF HYDROPHILISING SUBSTANCES CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

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Abstracts
EN
Research on gynaecological preparations followed that of optimising their pharmaceutical properties, which is beneficial for gynaecological powders. Gels obtained from powders containing lactic acid complexed with chitosan revealed a stoichiometric ratio 1:1, 2;1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyethylene glycol-400 increases the pH from 4.52 to 4.92 for 1:1 gels and from 2.54 to 3.41 for the 8:1 ratio. A modification of the composition of the tested powders containing 5% polyethylene glycol-400 increased the range of the dynamic viscosity of formulations suitably from 78 to 520 mPa.s for 1:1 gels and from 39 to 423 mPa.s for the 8:1 ratio. Measurements performed in a biopharmaceutical model revealed that the gels obtained from powders containing lactic acid complexed with chitosan are able to move from 25 to 28 cm.
Year
Volume
19
Pages
95-101
Physical description
References
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undetermined
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YADDA identifier
bwmeta1.element.psjd-8fe0caaf-1162-47a7-baec-49dfeab55526
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