Udział homocysteiny w patologii niektórych chorób neurologicznych

• Authors: Karina Kierkus-Dłużyńska

Title variants

EN

Role of homocysteine in the pathology of some neurological diseases

• Languages of publication: EN PL

Abstracts

EN

Lately the role of homocysteine in pathology of diseases, also neurological, seems to be very interesting. Homocysteine is an amino acid containing thiol group, produced in body by demethylation of methionine. An important role in its metabolism play vitamins from group B (vitamin B6 and B12), folic acid and enzymes: reductase and synthetase. The level of homocysteine depends on genetic and congenital factors. Normal concentration of homocysteine in serum for people under 60 years old is 5-15 μmol/l, for older it is higher. Recently there was found the correlation between the excess of homocysteine and the risk of vascular diseases, dementia. It is also interesting if the level of homocysteine changes in patients with Parkinson’s disease. It can also be teratogenic. It was found that in epileptic patients the level of homocysteine is higher. Antiepileptic drugs which induce cytochrome P450 cause increase in homocysteine levels.

PL

Ostatnio obserwuje się duże zainteresowanie homocysteiną i jej rolą w patologii chorób, także neurologicznych. Homocysteina jest siarkowym aminokwasem zawierającym grupę tiolową, powstającym w organizmie w wyniku demetylacji metioniny. W jej metabolizmie ważną rolę odgrywają witaminy z grupy B (witamina B6 i B12), kwas foliowy oraz enzymy z grupy reduktaz i syntetaz. Poziom homocysteiny zależny jest od czynników wrodzonych i nabytych. Prawidłowy poziom homocysteiny w surowicy krwi dla osób poniżej 60. roku życia wynosi 5-15 mmol/l, dla ludzi starszych dopuszcza się wyższy. Stwierdzono zależność między podwyższonym poziomem homocysteiny a ryzykiem chorób naczyniowych czy otępiennych. Zainteresowanie wzbudziło również zachowanie się poziomu homocysteiny u pacjentów z chorobą Parkinsona. Podwyższony poziom homocysteiny może mieć też działanie teratogenne. Niedawno zwrócono uwagę, że u pacjentów leczonych lekami przeciwpadaczkowymi poziom homocysteiny może być podwyższony. Leki przeciwpadaczkowe indukujące cytochrom P450 powodują wzrost stężenia homocysteiny w surowicy.

Keywords

EN

anticonvulsants; epilepsy; hiperhomocysteinemia; homocysteina; homocysteine; hyperhomocysteinemia; leki przeciwpadaczkowe; metabolism; metabolizm; padaczka

Discipline

• MEDICINE: MEDICINE

• Journal: Aktualności Neurologiczne
• Year: 2006
• Volume: 6
• Issue: 1
• Pages: 62-66

Contributors

author

Karina Kierkus-Dłużyńska

• Oddział Neurologii, Wojewódzki Szpital Specjalistyczny im. M. Kopernika, ul. Pabianicka 62, 93-513 Łódź, tel. [phone],

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• Document Type: article