Wybrane czynniki molekularne związane z przerzutowaniem raka jajnika

• Authors: Anna Markowska , Jolanta Lubin , Karolina Jaszczyńska-Nowinka , Janina Markowska

Title variants

EN

Selected molecular factors associated with metastases of ovarian cancer

• Languages of publication: EN

Abstracts

EN

Development of metastases is a typical feature of cancer progression and the main cause of treatment failure in cancer treatment. Due to their ability to settle far from original tumor location, cancer cells may preserve the feature of immortal cells, enabling survival of tumor and transition to chronic phase of the disease. Applying currently available techniques of topical treatment, such as surgery and radiotherapy, we are unable to control fully spread of cancer cells, while systemic chemotherapy even in chemosensitive tumors does not eradicate the disease in all cases. Ovarian cancer may spread by dissemination within the abdominal cavity and lymphatic vessels, resulting in distant metastases. The process of metastases’ development is extremely complex, depending on many different factors governing intercellular adhesion and acquisition of ability to move and migrate by cancer cells. Tumors with coexisting distant metastases are considered most advanced, which means also a grim prognosis for the patient. Mechanism of metastases’ development is the subject of several studies, attempting to identify factors which might lendthemselves for targeted therapy of cancers, including ovarian cancer. The paper presents genes, their products and other metastases-associated proteins: HER2 gene, AEG-1 gene, kisspeptin, E-cadherin, survivin, uPAR, clusterin, Met gene, claudins 3 and 4, kallikreins, SDF-1 gene. This paper is meant to systematize extensive knowledge on the development of metastases development and synthetic analysis of data concerning this process.

PL

Przerzutowanie jest cechą charakterystyczną progresji nowotworów złośliwych i główną przyczyną niepowodzeń w leczeniu raka. Dzięki zdolności do występowania w miejscach poza ogniskiem pierwotnym komórki nowotworowe mogą zachować cechę komórek nieśmiertelnych, co pozwala na przetrwanie nowotworu i nazwanie go chorobą przewlekłą. Stosując dostępne dziś metody leczenia miejscowego, takie jak chirurgia i radioterapia, nie jesteśmy w stanie w pełni kontrolować rozprzestrzeniania się komórek nowotworowych, a systemowa chemioterapia w chemiowrażliwych nowotworach nie zawsze „eradykuje” chorobę. Rak jajnika może szerzyć się poprzez rozsiew w jamie brzusznej oraz naczynia chłonne, dając przerzuty odległe. Proces przerzutowania jest niezmiernie złożony, wpływa na niego wiele różnych czynników decydujących o wzajemnym przyleganiu komórek do siebie, nabyciu zdolności ruchliwości i migracji przez komórki nowotworowe. Nowotwory, którym towarzyszą przerzuty odległe, są klasyfikowane jako najbardziej zaawansowane, co oznacza jednocześnie złe rokowanie dla pacjenta. Mechanizm przerzutowania jest przedmiotem wielu badań mających na celu wyłonienie czynników, które mogą być tarczą dla terapii celowanych nowotworów, w tym raka jajnika. W artykule przedstawiono geny i ich produkty oraz inne białka związane z przerzutowaniem: gen HER2, gen AEG-1, kisspeptynę, kadherynę-E, surwiwinę, uPAR, klusterynę, gen Met, klaudyny 3 i 4, kalikreiny, gen SDF-1. Celem pracy było usystematyzowanie obszernej wiedzy na temat przerzutowania oraz syntetyczna analiza danych dotyczących tego procesu.

Keywords

EN

AEG-1 gene; E-cadherin; HER2 gene; Met gene; SDF-1 gene; claudins 3 and 4; clusterin; gen AEG-1; gen HER2; gen Met; gen SDF-1; kadheryna-E; kalikreiny; kallikreins; kisspeptin; kisspeptyna; klaudyny 3 i 4; klusteryna; metastases; ovarian cancer; przerzuty nowotworowe; rak jajnika; survivin; surwiwina; uPAR

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Current Gynecologic Oncology
• Year: 2012
• Volume: 10
• Issue: 3
• Pages: 236-243

Contributors

author

Anna Markowska

• Klinika Perinatologii i Chorób Kobiecych, Uniwersytet Medyczny w Poznaniu. Kierownik: prof. dr hab. n. med. Krzysztof Drews

author

Jolanta Lubin

• Katedra Onkologii, Uniwersytet Medyczny w Poznaniu. Kierownik: prof. dr hab. n. med. Janina Markowska

author

Karolina Jaszczyńska-Nowinka

• Katedra Onkologii, Uniwersytet Medyczny w Poznaniu. Kierownik: prof. dr hab. n. med. Janina Markowska

author

Janina Markowska

• Katedra Onkologii, Uniwersytet Medyczny w Poznaniu. Kierownik: prof. dr hab. n. med. Janina Markowska

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• Document Type: article