Synthesis, effect of substituents and antimicrobial activities of some 4-bromophenyl chalcones

• Authors: S. Vijayakumar , G. Vanangamudi , G. Thirunarayanan
• Languages of publication: EN

Abstracts

EN

Elven (E)-1-(4-bromophenyl)-3-(substituted phenyl)-2-propen-1-ones are formed using sodium hydroxide catalyzed Aldol condensation between 4-bromoacetophenone and substituted benzaldehyde. The production of these chalcone compounds are above 90%. These α, β unsaturated ketones were specified by their physical constants and spectral data (UV, IR, 1H and 13C-NMR). Hammett substituted constants (σ, σ+, σI & σR and F and R parameters have been used for correlating the spectral values of these α, β unsaturated ketones by using single and multi-linear regression analysis. The impacts of substituents on the spectral data have been known on statistical analysis. By using Bauer-Kirby method the anti-microbial activities of these (E)-1-(4-bromophenyl)-3-(substituted phenyl)-2-propen-1-ones compounds are estimated.

Keywords

EN

(E)-1-(4-bromophenyl)-3-(substituted phenyl)-2-propen-1-ones; UV spectra; IR spectra; NMR spectra; Substituent effects; Antimicrobial activities

Discipline

• CHEMISTRY: CHEMISTRY

• Journal: World Scientific News
• Year: 2016
• Volume: 54
• Pages: 132-152

Contributors

author

S. Vijayakumar

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur - 608102, Chidambaram, India

author

G. Vanangamudi

• PG and Research Department of Chemistry, Government Arts College, C-Mutlur - 608102, Chidambaram, India

author

G. Thirunarayanan

• Department of Chemistry, Annamalai University, Annamalainagar - 608002, India,

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• Document Type: article