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2016 | 21 | 160-164
Article title

ASSESSMENT OF PHARMACEUTICAL PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

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Abstracts
EN
pH of gels ranged from 3.92 to 4.44 for gels 1:1 and from 2.36 to 2.84 for 8:1 ratio. The addition of 20%, 23% or 25% poloxamer 407 increases the pH ranged from 4.00 to 4.91 for gels with 1:1 ratio and from 2.56 to 3.42 for 8:1 ratio. Rheological studies demonstrated that the investigated gels obtained from powders have the dynamic viscosity ranged from 53 mPa*s to 398 mPa*s for the 1:1 stoichiometric ratio in the complex and from 19 mPa*s to 242 mPa*s for 8:1 ratio. The addition of calcium alginate with polyoxyethylene glycol-200 reduces the pH and maintains high dynamic viscosity. The thermosensitive gels obtained from thermosensitive powders shows high adhesion and are difficult to separate from the probe.
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Volume
21
Pages
160-164
Physical description
Contributors
  • Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy, The “Silesian Piasts” memorial Medical University of Wroclaw, Borowska 211A Street, 50-556 Wrocław, Poland., katarzynamj@poczta.onet.pl
References
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-88fcfb74-97f6-48af-a3c8-b1fc0be47e83
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