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Journal

2021 | 11 | 3 | 61-67

Article title

Cardiovascular complications during the treatment of castration-resistant prostate cancer with the use of modern antiandrogens: abiraterone acetate and enzalutamide

Content

Title variants

Languages of publication

EN

Abstracts

EN
Modern antiandrogens: abiraterone acetate (inhibitor of CYP17 cytochrome) and enzalutamide (irreversible inhibitor of androgen receptor) are the drugs that are increasingly often administered in treatment of castration-resistant prostate cancer. Despite their clinical efficacy, especially in terms of prolonged survival and improved quality of life of patients, they pose of problem for a practicing oncologist such as possible cardiovascular complications (particularly arterial hypertension), which may lead to the cessation of this form of therapy. This article provides a brief overview of the mechanisms responsible for the above complications, including practical recommendations in the event such complications arise. A simple scheme of action for control of cardiovascular risk factors has been presented, which can improve the prognosis in this population of patients.

Discipline

Publisher

Journal

Year

Volume

11

Issue

3

Pages

61-67

Physical description

Contributors

  • 1. Department of Internal Medicine, Gastroenterology and Oncological Cardiology, Warmian- -Masurian Cancer Center of the Ministry of the Interior And Administration’s Hospital, Olsztyn, Poland. 2. Pulmonology Clinic, Collegium Medicum, Univesity of Warmia and Mazury, Olsztyn, Poland
  • Oncology and Immunooncology Clinic, Warmian-Masurian Cancer Center of the Ministry of the Interior and Administration’s Hospital, Olsztyn, Poland

References

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  • 3. Nguyen PL, Alibhai SMH, Basaria S et al. Adverse effects of androgen deprivation therapy and strategies to mitigate them. Eur Urol. 2015; 67(5): 825-36.
  • 4. Tzortzis V, Samarinas M, Zachos I et al. Adverse effects of androgen deprivation therapy in patients with prostate cancer: focus on metabolic complications. Hormones (Athens). 2017; 16: 115-23. https://doi.org/10.14310/horm.2002.1727.
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  • 11. Zhu X, Wu S. Risk of hypertension in Cancer patients treated with Abiraterone: a meta-analysis. Clin Hypertens. 2019; 25: 5. https://doi.org/10.1186/s40885-019-0110-3.
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  • 16. Beer TM, Armstrong AJ, Rathkopf DE et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014; 371: 424-33. https://doi.org/10.1056/NEJMoa1405095.
  • 17. Hussain M, Fizazi K, Saad F et al. Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. N Engl J Med. 2018; 378: 2465-74. https://doi.org/10.1056/NEJMoa1800536.
  • 18. Salem JE, Yang T, Moslehi JJ et al. Androgenic effects on ventricular repolarization: a translational study from the international pharmacovigilance database to iPSC-cardiomyocytes. Circulation. 2019; 140: 1070-80. https://doi.org/10.1161/CIRCULATION AHA.119.040162.
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  • 25. Gill D, Gaston D, Bailey E et al. Efficacy of eplerenone in the management of mineralocorticoid excess in men with metastatic castration-resistant prostate cancer treated with abiraterone without prednisone. Clin Genitourin Cancer. 2017; 15(4): e599-602.
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Document Type

article

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.psjd-88949ed3-b647-4381-87e9-3e43e92ebf7c
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