PL EN


Preferences help
enabled [disable] Abstract
Number of results
2010 | 15 | 107 - 116
Article title

KINETICS OF ACTIVE SUBSTANCE RELEASE FROM FLAT BIOPOLYMER MULTILAYER FILMS

Content
Title variants
Languages of publication
EN
Abstracts
EN
Abstract. Polymer films were made of different biodegradable materials. Solid support of model active substance (salicylic acid) was unmodified and modified (crosslinked with glutaraldehyde) chitosan and outside layers were polylactid acid (PLA). The aim of the study was to obtain the controlled release kinetics of active substance, in medium of pH 5.6 which is similar to conditions occurring on the human skin surface. The chitosan films were investigated with swelling kinetics while multilayer films were studied with release kinetics of active substance (salicylic acid). The amount of salicylic acid released from film was measured using a UV-VIS spectrophotometer. The appropriate mathematical model was also adjusted to the experimental points. The results prove that the swelling process follows the first order kinetics but the results of release process are fitted with Peppas model.
Year
Volume
15
Pages
107 - 116
Physical description
Contributors
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland
author
  • Faculty of Process and Environmental Engineering, Technical University of Lodz, ul. Wolczanska 213, 90-924, Lodz, Poland
References
  • Yogeshvar N. K., Guy R. H.; (2001) ‚Modeling transdermal drug release’, Advanced Drug Reviews 48 159 – 172.
  • Farmakopea Polska wyd. VI część podstawowa opublikowana przez Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, Polskie Towarzystwo Farmaceutyczne – Warszawa 2002.
  • Balcerzak J., Michalak I., Tylman M., Mucha M.; (2009) ‘Controlled drug release from biopolymer systems of various geometry based on chitosan’, Advances in Chitin Science, (Euchis 2009), vol. XI, p.110.
  • Costa P., et al.; (2001) Review: Modeling and comparison of dissolution profiles, European Journal of Pharmaceutical Sciences 13 pp. 123-133.
  • Lao L. L., Venkatraman S. S., Peppas N. A.; (2008) ‘Modeling of drug release from biodegradable polymer blends’, European Journal of Pharmaceutics and Biopharmaceutics, 70 pp. 796-803.
  • Shantha K. L., Bala U., Pandurange R. K.; (1994) ‘Tailor-made chitosans for drug delivery’, Eur. Polym. J. Vol. 31, No. 4. pp. 377-382.
  • Shu X. Z., Zhu K. J.; (2001) ‘The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release’, European Journal of Pharmaceutics and Biopharmaceutics 54 pp. 235-243.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-86953e8f-9fa5-484f-b6b9-5d5cb2acd99a
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.