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Number of results

Journal

2018 | 8 | 4 | 108-113

Article title

Erythropoietin and the erythropoietin receptor, and drug resistance and progression of the neoplastic disease

Content

Title variants

Languages of publication

EN

Abstracts

EN
Preclinical studies conducted over the past 10 years have shown that EPO is not only a hormone that regulates erythropoiesis, a major growth factor, but also a cytoplasm with pleiotropic activity that also affects cancer cells. The expression of EPO and its receptor (EPOR) occurs in many cancers of various origins. The EPO/EPOR system is active in many cancer cells and is involved in the modification of molecular signaling pathways and the stimulation of growth, survival, motility and the ability to create metastases. EPO can also increase the resistance of cancer cells in vitro and in vivo to chemotherapy and radiotherapy.

Discipline

Publisher

Journal

Year

Volume

8

Issue

4

Pages

108-113

Physical description

Contributors

author
  • 1st Radiation and Clinical Oncology Department, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland
  • Department of Bone Marrow Transplantation and Hematology-Oncology, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland
  • 1st Radiation and Clinical Oncology Department, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland
  • 1st Radiation and Clinical Oncology Department, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland
  • 1st Radiation and Clinical Oncology Department, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland

References

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Document Type

article

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.psjd-8632fff6-93f4-49b8-8497-178ace2e615d
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