O-GlcNAcylation, steroid hormone receptors and cancer

• Authors: Jacek Wilkosz , Waldemar Różański , Magdalena Bryś , Ewa Forma

Title variants

PL

O-GlcNAcylacja, receptory dla steroidów i nowotwory

• Languages of publication: EN

Abstracts

EN

The addition of a single residue of O-linked N-acetylglucosamine (O-GlcNAc) to serine or threonine is a post-translational modification (O-GlcNAcylation) of proteins found in the cytoplasm or the nucleus. This dynamic modification is dependent on the environmental glucose concentration. O-GlcNAc modification is catalysed by a glycosyltransferase named O-linked N-acetylglucosaminyltransferase (OGT), and O-GlcNAc residue is removed by the antagonistic enzyme β-N-acetylglucosaminidase (O-GlcNAcase; OGA). Cytosolic O-GlcNAcylation is important for the proper transduction of signalling cascades, whereas nuclear O-GlcNAc is crucial for the transcriptional regulation. O-GlcNAcylation is also important in the regulation of the transcriptional activity of steroid hormone receptors. Both O-GlcNAc transferase and O-GlcNAcase are found in all tissues and have been shown to be essential for development in vertebrates, which underscores their fundamental roles in vital processes as well as in pathological conditions such as neoplastic transformation.

PL

Glikozylacja polegająca na przyłączeniu pojedynczych reszt β-N-acetylo- D-glukozaminy do reszt seryny lub treoniny polipeptydu wiązaniem O-glikozydowym (O-GlcNAc), jest powszechną modyfikacją białek jądrowych i cytoplazmatycznych. Modyfikacja ta pozostaje w ścisłym związku z dostępnością glukozy. β-N-acetyloglukozaminylotransferaza (O-GlcNAc transferaza, OGT) jest enzymem odpowiedzialnym za katalityczne przyłączenie reszt O-GlcNAc, natomiast β-N-acetylo-D-glukozaminidaza (OGA) reszty te odłącza. Proces O-GlcNAcylacji zachodzący w cytozolu jest istotny z punktu widzenia transmisji sygnału komórkowego, natomiast przyłączanie reszt O-GlcNAc na terenie jądra wpływa na proces transkrypcji. Wykazano, że proces O-GlcNAcylacji moduluje regulację aktywności transkrypcyjnej receptorów hormonów steroidowych. Oba enzymy, O-GlcNAc transferaza i β-N-acetylo- D-glukozaminidaza wykrywane są we wszystkich tkankach i jak wykazano, niezbędne są dla prawidłowego rozwoju organizmu, jak również mogą uczestniczyć w procesie transformacji nowotworowej.

Keywords

EN

O-GlcNAcylacja; O-GlcNAcylation; cancer; nowotwór; receptory dla steroidów; steroid hormone receptors

Discipline

• MICROBIOLOGY_&_CELL_BIOLOGY: MICROBIOLOGY & CELL_BIOLOGY

• Publisher: Łódzkie Towarzystwo Naukowe
• Journal: Folia Medica Lodziensia
• Year: 2013
• Volume: 40
• Issue: 1
• Pages: 133-149

Contributors

author

Jacek Wilkosz

• Oddział Urologii Ogólnej, Onkologicznej i Czynnościowej, Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi, Pabianicka 62, 93-513 Łódź

author

Waldemar Różański

• Oddział Urologii Ogólnej, Onkologicznej i Czynnościowej, Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi, Pabianicka 62, 93-513 Łódź

author

Magdalena Bryś

• Katedra Cytobiochemii, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki, Pomorska 141/143, 90-236 Łódź

author

Ewa Forma

• Katedra Cytobiochemii, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki, Pomorska 141/143, 90-236 Łódź

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• Document Type: paper