COMPARATVE URIC ACID LOWERING STUDIES OF ALLOPURINOL WITH AN INDIGENOUS MEDICINAL PLANT IN RABBITS

• Authors: IMRAN SHAIR MOHAMMAD , SANA LATIF , MUHAMMAD YAR , FAIZA NASAR , IRSHAD AHMAD , MUHAMMAD NAEEM
• Languages of publication: EN

Abstracts

EN

The aim of this research was to carry out a comparative study of lowering of uric acid by the use of dried powder of Colchicum luteum and allopathic drug (allopurinol) in rabbits, to determine whether herbal drugs can be used by patients instead of allopathic drugs. The herbal medicine, dried corm powder of Colchicum luteum 2.5 mg/kg/day and dried powder of allopurinol 2 mg/kg/day an allopathic medicine, was used in the study. The results of these medicines were observed in animal model, using 12 adult rabbits, which were divided into three groups A, B and C, respectively, where group C was taken as control. The SPSS version 17 was used for statistical analysis and analysis of variance (ANOVA) was used for comparing the data in different groups and the level of significance was 5%. It was resulted that dried corm of Colchicum luteum significantly reduced the uric acid in adult rabbits as reduced by allopathic medicine ñ allopurinol. In the light of present research we concluded that the herbal medicines can be used in lieu of allopathic drugs. Thus, the risk of side effects that are associated with the prolonged use of allopathic drugs can be minimized.

Keywords

EN

Colchicum luteum; allopurinol; herbal medicine; reduction in uric acid

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2014
• Volume: 71
• Issue: 5
• Pages: 855-859

Dates

published

2014

Contributors

author

IMRAN SHAIR MOHAMMAD

author

SANA LATIF

author

MUHAMMAD YAR

author

FAIZA NASAR

author

IRSHAD AHMAD

author

MUHAMMAD NAEEM

References

• 1. Becker M.A., Schumacher H.R., Wortmann R.L., MacDonald P.A., EustaceD., PaloW.A., StreitJ., Joseph-RidgeN.: New Eng. J. Med. 353, 2450 (2005).
• 2. Kutzing M.K., Firestein B.L.: J. Pharm. Exp. Ther. 324, 1 (2008).
• 3. Kim S.Y., Guevara J.P., Kim K.M., Choi H.K., Heitjan D.F., Albert D.A.: Arthritis Rheum. 61, 885 (2009).
• 4. Feig D.I., Kang D.H., Johnson R.J.: New Eng. J. Med. 359, 1811 (2008).
• 5. Krishnan E., Kwoh C.K., Schumacher H.R., Kuller L.: Hypertension49, 298 (2007).
• 6. Gaffo A.L., Edwards N.L., Saag K.G.: Arthritis Res. Ther. 11, 240 (2009).
• 7. Eggebeen A.T. : Am. Fam. Physician76, 801 (2007).
• 8. Grayzel A.I., Liddle L., Seegmiller J.E.: New Eng. J. Med. 265, 763 (1961).
• 9. Eraly S.A., Vallon V., Rieg T., Gangoiti J.A., Wikoff W.R., Siuzdak G., BarshopB.A., NigamS.K.: Physiol. Genomics 33, 180 (2008).
• 10. Alvares-Lario B., Macarron-Vicente J.: Rheumatology49, 2010 (2010).
• 11. Hayashi S., Fujiwara S., Noguchi T.: Cell. Biochem. Biophys. 32, 123 (2000).
• 12. Choi H.K., Mountand D.B., Reginato A.M.: Ann. Intern. Med. 143, 499 (2005).
• 13. Wortmann R.L.: Curr. Opin. Rheumatol. 17, 319 (2005).
• 14. Rawlins M.D., Smith S.E.: Br. J.Pharmacol. 48, 693 (1973).
• 15. Nair V., Singh S., Gupta Y.K.: J. Ethnopharmacol. 133, 303 (2011).
• 16. Adnan S.M., Khan A.A., Latif A., Shiwari Z.K.: Lyonia11, 91 (2006).
• 17. Khan H., Tariq S.A., Khan M.A.: J. Med. Plant. Res. 5, 7031 (2011).
• 18. Singh P.B., Aswal B.S.: J. Econ. Taxon. Bot. 18, 715 (1994).
• 19. Perheentupa J., Raivio K.: Lancet 2, 528 (1967).
• 20. Trivedi R. Berta E., Rebar L.: Clin. Chem. 22, 1223 (1976).
• 21. Machado-Vieira R., Soares J.C., Lara D.R., Luckenbaugh D.A., Busnello J.V., Marca G., CunhaA. et al.: J. Clin. Psychiatry69, 1237 (2008).
• 22. Pea F.: Contrib. Nephrol. 147, 35 (2005).
• 23. Chommadov B., Yusupov M.K., Sadykov A.S.: Chem. Nat. Comp. 6, 77 (1970).
• 24. Rao P., Falk L.A., Dougherty S.F., Sawada T., Pluznik D.H.: J. Immunol. 159, 3531 (1997).

• Document Type: article