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2018 | 18 | 1 | 81–86
Article title

Pozycja agomelatyny w leczeniu depresji

Content
Title variants
EN
Agomelatine in the management of depression
Languages of publication
PL
Abstracts
EN
Various antidepressants are available on the market, most of them relying on a few common mechanisms of action. Since response to treatment in a large percentage of patients is not satisfying, the emergence of drugs with a novel mechanism of action, as is the case with agomelatine, invariably offers new hope. The article offers a review of the results of meta-analyses and placebo-controlled studies as well as several open-label trials concerning given aspects of therapy. The reviewed studies have all been published over the recent years, starting in 2013. The meta-analyses have yielded equivocal results, yet the newer studies seem to point to the high efficiency of agomelatine. Importantly, the validity of earlier concerns regarding the significant hepatotoxicity of agomelatine has not been confirmed. The results of placebo-controlled trials have fairly unanimously demonstrated the effectiveness and safety of agomelatine to be in no way inferior to that of selective serotonin reuptake inhibitors. The recent studies investigating the effect of agomelatine on anhedonia have all been open-label trials, with agomelatine not compared with other antidepressants, hence it is difficult to interpret the outcomes unequivocally.
PL
Na rynku dostępnych jest wiele leków przeciwdepresyjnych, ale wykorzystują one jedynie kilka wspólnych mechanizmów działania. Ponieważ znaczny odsetek pacjentów nie reaguje wystarczająco dobrze na stosowane leki, pojawienie się leku o nowym mechanizmie działania, takiego jak agomelatyna, zawsze budzi nadzieje. W artykule przedstawiono wyniki metaanaliz i badań kontrolowanych, a także kilku badań otwartych dotyczących pewnych szczególnych aspektów terapii. Zaprezentowane badania zostały opublikowane w ostatnich latach – w roku 2013 i później. Wyniki metaanaliz nie są jednoznaczne, ale nowsze publikacje mogą wskazywać na wysoką skuteczność agomelatyny. Co istotne, nie potwierdzają się wcześniejsze opinie o znacznej hepatotoksyczności leku. Rezultaty badań kontrolowanych niemal jednoznacznie wskazują, że pod względem skuteczności i bezpieczeństwa agomelatyna nie ustępuje lekom przeciwdepresyjnym z grupy selektywnych inhibitorów wychwytu zwrotnego serotoniny. Przeprowadzone w ostatnich latach badania dotyczące wpływu agomelatyny na anhedonię mają charakter badań otwartych, agomelatyna nie była w nich porównywana z innymi lekami przeciwdepresyjnymi, stąd też trudno jednoznacznie zinterpretować uzyskane wyniki.
Discipline
Year
Volume
18
Issue
1
Pages
81–86
Physical description
References
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Document Type
article
Publication order reference
YADDA identifier
bwmeta1.element.psjd-85412d75-c716-4d3d-bb03-377e3a3ea35d
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