The role of activation of insulin-like growth factors in colorectal cancer

• Authors: Katarzyna Walkiewicz , Ewa Nowakowska-Zajdel , Joanna Strzelczyk , Michał Walczak , Angelika Copija , Karolina Janion , Małgorzata Muc-Wierzgoń
• Languages of publication: EN

Abstracts

EN

Co-occurrence of metabolic disorders is a recognized risk factor for the development of colorectal cancer which is currently the leading cause of morbidity due to malignant neoplasms in the world. The pathogenesis of colorectal cancer is not well understood yet. Among the postulated neoplastic mechanisms is the activation of insulin-like growth factors, with both epidemiological and clinical observations of their role. In this paper, the authors synthesize the current knowledge about the importance of activation of insulin-like growth factors in the development of colorectal cancer.

Keywords

EN

IGF-receptors; colorectal cancer; insulin-like growth factors; metabolic disorders

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2017
• Volume: 7
• Issue: 3
• Pages: 116-120

Contributors

author

Katarzyna Walkiewicz

• Department and Clinic of Internal Diseases, Public Health Division in Bytom, Medical University of Silesia in Katowice

author

Ewa Nowakowska-Zajdel

• 1. Department of Clinical Oncology, No. 4 Provincial Specialist Hospital in Bytom. 2. Diet-Related Diseases Prevention Unit, Public Health Division in Bytom, Medical University of Silesia in Katowice

author

Joanna Strzelczyk

• Department and Clinic of Medical and Molecular Biology, Faculty of Medicine and Dental Medicine in Zabrze, Medical University of Silesia in Katowice

author

Michał Walczak

• Department of General and Gastroenterological Surgery, No. 1 Specialist Hospital in Bytom

author

Angelika Copija

• 1. Department of Clinical Oncology, No. 4 Provincial Specialist Hospital in Bytom. 2. Diet-Related Diseases Prevention Unit, Public Health Division in Bytom, Medical University of Silesia in Katowice

author

Karolina Janion

• Department of Clinical Oncology, No. 4 Provincial Specialist Hospital in Bytom

author

Małgorzata Muc-Wierzgoń

• Department and Clinic of Internal Diseases, Public Health Division in Bytom, Medical University of Silesia in Katowice

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• Document Type: article