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2010 | 15 | 127 - 134
Article title

THE INFLUENCE OF DIFFERENT KINDS OF CHITOSAN ON BIOAVAILABILITY OF ANTI-INFLAMMATORY DRUGS

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EN
Abstracts
EN
Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind acid drugs. The aim of the study was to determine the binding capability of Ketoprofen and Naproxen sodium salt by chitosans contained in weight-loss supplements. The drug absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of drugs by chitosan ranged from 92% to 96% depending on the environmental pH. The highest absorption rate was observed at above pH 7. Concluding, the studies confirmed that the investigated drugs interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.
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15
Pages
127 - 134
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author
  • Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw, meler@ktpl.am.wroc.pl
References
  • Meler J., Pluta J., Ulanski P., Krotkiewski M.; Fat- the binding capacity of ninths - the modified and modified chitosans. In: Progress he Chemistry and Application of Chitin and its Derivatives. Vol. IX (ed.: H. Struszczyk). Polish Chitin Society. 2003 Lodz. pp. 129-136.
  • Roberts G. A. F., Domszy J. G.; Determination of the viscosimetric constants for chitosan. Int. J. Biol. Macromol. 4. 1982 p. 374.
  • Filipkowska U., Klimiuk E., Grabowski S., Siedlecka E.; Adsorption of reactive dyes by modified chitin from aqueous soutions Pol. J. Environ. Stud. 11, 2002 pp. 315-323.
  • Rhazi M., Desbrieres J., Tolaimate A., Rinaudo M., Vottero P., Alagui A., El Meray M.; Influence of the nature of the metal ions on the complexation with chitosan. Application to the treatment of liquid waste Eur. Polym. J. 38, 2002 pp. 1523-1530.
  • Meler J., Pluta J.; The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical patternel of digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk). Polish Chitin Society. Łódź.2004 pp. 131-137.
  • Mccurdy J. D.; FDA and the use of chitin and chitosan derivative.- In: Advances in Chitin and Chitosan. Elsevier Applied Science. London 1992 pp. 659-662.
  • Torzsas T. L., Kendall C. W., Sugano M., Iwamoto Y., Rao A.V.; The influence of high and low molecular weight chitosan on colonic cell proliferation and abberant crypt foci development in CF1 mice.- Food Chem. Toxicol. 34. 1996 pp. 73-77.
  • Meler J. Pluta J., Krotkiewski M.; The influence of various kinds of chitosan on fat binding ability. 4th World Meeting on Pharmaceutics. Biopharmaceutics and Pharmaceutical Technology. Florence. 2002 pp. 617-618.
  • Meler J., Pluta J., Ulański P., Krotkiewski M.; Vozdejstvie raznych form chitozana na sposobnost’ svjazyvanija žirov.Modern perspectives in chitin and chitosan studies : Proceedings of the VIIth International Conference. St. Petersburg - Repino. pp. 258-260, Moscow VNIRO Publishing. 2003.
  • Meler J., Pluta J.; Influence on action of enzyme of feed wire in research chitosans in vitro. In: Biomaterials in Regenerative Medicine Vol. 6 (ed.: A. Nadolny). Polish Academy of Sciences. Vienna p 2006 pp. 173-177.
  • Meler J.; Influence of different changes on bioavailability of medicine chitosans antiphlogistic drugs. In:Progress of Chemistry and Application of Chitin and its Derivatives. Vol. XIII (ed.: M. Jaworska). Polish Chitin Society. Łódź 2008. pp. 81-88.
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article
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YADDA identifier
bwmeta1.element.psjd-83226ee2-53b9-4fbf-826c-b178747ab7e5
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