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2018 | 23 | 120 - 129
Article title

THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

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Abstracts
EN
The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.
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Year
Volume
23
Pages
120 - 129
Physical description
Contributors
  • Department of Drugs Form Technology, Faculty of Pharmacy, The “Silesian Piasts” Memorial Wroclaw Medical University, katarzynamj@poczta.onet.pl
References
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  • [3] Donders GGG, Larson PG, Platz – Christensen JJ, Hallen A, Meijden W, Wölner – Hanssen P; (2009) Variability in diagnosis of clue cells, lactobacillary grading and white blood cells in vaginal wet smears with conventional bright light and phase contrast microscopy. Eur. J. Obstet. Gynecol. Reprod. Biol. 145, 109 – 112. DOI.org/10.1016/j.ejogrb.2009.04.012
  • [4] Kubis AA, Małolepsza-Jarmołowska K; (1996) Studies on gynecological hydrophiling preparations comprising lactic acid. Part 1: Effects of lactic acid and hydrophiling agents on physical and chemical properties of methylcellulose gels. Pharmazie 51, 989 – 990.
  • [5] Małolepsza-Jarmołowska K, Kubis AA; (1999) Studies on gynecological hydrophilic lactic acid preparations. Part 2: Effects of Eudragit® E-100 on properties of methylcellulose gels. Pharmazie 54, 441 – 443.
  • [6] Małolepsza-Jarmołowska K, Kubis AA; (2000) Studies on gynaecological hydrophilic lactic acid preparations. Part 3: Effects of chitosan on the properties of methylcellulose gels. Pharmazie 55, 610 – 611.
  • [7] Małolepsza-Jarmołowska K, Kubis AA; (2001) Studies on gynaecological hydrophilic lactic acid preparations. Part 4: Effects of polyvinyl pyrrolidone K-90 on properties of methylcellulose gels. Pharmazie 56, 160 – 162.
  • [8] Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 260 – 262.
  • [9] Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 6: Use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 334-336.
  • [10] Małolepsza-Jarmołowska K; (2006) Studies on gynaecological hydrophilic lactic acid preparations. Part 7: Use of chitosan as lactic acid carrier in intravaginal tablets (globuli vaginales). Pharmazie 61, 780 - 782.
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  • [12] Małolepsza-Jarmołowska K; (2010) The effect of poloxamer 407 on the properties of hydrophilic gels containing lactic acid complexed with chitosan. Monograph vol. XV ed. by M. Jaworska „Progress on Chemistry and Application of Chitin and Its Derivatives“ 15, 143-148.
  • [13] Małolepsza-Jarmołowska K; (2014) Research of pharmaceutical properties of hydrophilic powders containing lactic acid complexed with chitosan „Progress on Chemistry and Application of Chitin and Its Derivatives“ 14, 79-86 vol. XIX, ed. by M. Jaworska DOI:10.15259/PCACD.19.09
  • [14] Małolepsza-Jarmołowska K; (2017) Influence of a pectin on the properties of hydrophilic powders containing a lactic acid-chitosan complex „Progress on Chemistry and Application of Chitin and Its Derivatives“ 17, 135-142 vol. XXII, ed. by M. Jaworska DOI:10.15259/PCACD.22.13
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article
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YADDA identifier
bwmeta1.element.psjd-81e84f75-1d9a-4bc8-9da4-1ec3a1593c00
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