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2019 | 126 | 291-298
Article title

Synthesis, characterization and biological property of 3-(5-bromothiophen-2-yl)-6-phenyl-1,7a-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives

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A library of novel 3-(5-bromothiophen-2-yl)-6-phenyl-1,7a-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole were synthesized in excellent yields via domino one-pot two component reactions of 4-amino-3-(5-bromothiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thiol and benzoic acid derivatives respectively. A triazolo-thiadiazole system may be viewed as a cyclic analogue of two very important components - thiosemicarbazide and biguanide which often display diverse biological activities. The significant advantages of this reaction include one-pot process, simple work-up procedure, excellent yields and no column chromatographic purification. All intermediates and final compounds were confirmed by 1H NMR, 13C NMR, Mass Spectroscopy methods and IR analysis.
Physical description
  • Chemical Research Laboratory Shree U.P.E.T Mahila Sci. College Dhrol, Gujarat, India
  • Department of Chemistry, M. M. Science College Morbi, Gujarat, India
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