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2014 | 19 | 15-22
Article title

TECHNOLOGY OF PREPARATION AND EVALUATION OF KETOPROFEN-CHITOSAN SOLID DISPERSION

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EN EN
Abstracts
EN
The aim of the study was to investigate the effect of chitosan on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in physical mixtures at the drug to polymer ratios of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; the mean amount of dissolved ketoprofen and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multifold increase (33 times) in ketoprofen solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of ketoprofen in the presence of chitosan at the weight ratio 1:9 increased with the decrease of the molecular weight of the chitosan. The results obtained may help to develop new technologies for ketoprofen preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
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Year
Volume
19
Pages
15-22
Physical description
Contributors
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw, bamag@interia.pl
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw
References
  • 1. Woskowicz M; (2008) Biofarmaceutyczny system klasyfikacji (BCS) jako nowoczesna metoda oceny właściwości fizykochemicznych i farmakokinetycznych środków leczniczych. Farmacja Polska 64, 191-195.
  • 2. Amidon GL, Lennernäs H, Shah VP, Crison JR; (1995) A theoretical basis for a Biopharmaceutical Drug Classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12, 413-420.
  • 3. Nasser S., Sameen LH, Ghareeb MM.; (2012) Preparation and evaluation of oral disintegrating tablets of ketoprofen by direct compression. Iraqi J Pharm Sci 21, 63-68.
  • 4. Mogal SA, Gurjar PN, Yamgar DS, Kamod AC; (2012) Solid dispersion technique for improving solubility of some poorly soluble drugs. Der Pharmacia Lettre 4, 1574-1586.
  • 5. Singh S, Baghel RS, Yadav L; (2011) A review on solid dispersion. Int. J. Pharm & Life Sci 2, 1078-1095.
  • 6. Kini AG, Dixit M., Kulkarni PK.; (2011) Enhancement of solubility and dissolution rate of poorly water soluble drug by spray drying using different grade of chitosan. Int J Pharm Pharm Sci, 3, Suppl. 2, 231-235.
  • 7. Sonia TA, Chandra PN, Sharma; (2011) Chitosan and its derivatives for drug delivery perspective. Adv Polym Sci. 243, 23-54.
  • 8. Polish Pharmacopoeia (2011) The Office for Registration of Medicinal Products, Medical Devices and Biocidal Products, Warsaw, Poland. Vol. 9.
Document Type
article
Publication order reference
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YADDA identifier
bwmeta1.element.psjd-7f1b0fe6-8419-4f77-b832-234fc5784871
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