DEVELOPMENT OF MUCOADHESIVE CHITOSAN-BASED DRUG DELIVERY SYSTEM

• Authors: Mariya Konovalova , Balzhima Shagdarova , Anastasia Zubareva , Alexander Generalov , Maria Grechikhina , Elena Svirshchevskaya
• Languages of publication: EN

Abstracts

EN

Chitosan is a highly versatile biopolymer characterised by low toxicity, biocompatibility, and slow but complete biodegradation in the human body, possessing multiple reactive groups. One of the most well-known properties of positively charged chitosan derivatives is their ability to bind mucous membranes. The aim of this work was the analysis of mucoadhesion of unmodified 20 kDa chitosan and its hydrophobic (HC) and hydrophobic quaternised (QHC) derivatives in vitro and ex vivo. Unmodified chitosan formed large aggregates in vitro in keratinocyte and colon cell cultures and ex vivo in murine small intestine and muscle explants. At the same time, HC and especially QHC bound cells in vitro and ex vivo in a fine dotted manner, as evidenced by confocal microscopy. Such a pattern of hydrophobic derivatives distribution provides the possibility to develop mucoadhesive drug delivery systems with increased local drug release and improved chitosan biodegradation.

Keywords

EN

chitosan; drug delivery systems; hexanoylchitosan; mucoadhesion; quaternised chitosan

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2018
• Volume: 23
• Pages: 103 - 113

Contributors

author

Mariya Konovalova

• Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

author

Balzhima Shagdarova

• Institute of Bioengineering, Research Centre of Biotechnology of the Russian Academy of Sciences

author

Anastasia Zubareva

• Institute of Bioengineering, Research Centre of Biotechnology of the Russian Academy of Sciences

author

Alexander Generalov

• Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

author

Maria Grechikhina

• Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

author

Elena Svirshchevskaya

• Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

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• Document Type: article