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2018 | 23 | 103 - 113
Article title

DEVELOPMENT OF MUCOADHESIVE CHITOSAN-BASED DRUG DELIVERY SYSTEM

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Abstracts
EN
Chitosan is a highly versatile biopolymer characterised by low toxicity, biocompatibility, and slow but complete biodegradation in the human body, possessing multiple reactive groups. One of the most well-known properties of positively charged chitosan derivatives is their ability to bind mucous membranes. The aim of this work was the analysis of mucoadhesion of unmodified 20 kDa chitosan and its hydrophobic (HC) and hydrophobic quaternised (QHC) derivatives in vitro and ex vivo. Unmodified chitosan formed large aggregates in vitro in keratinocyte and colon cell cultures and ex vivo in murine small intestine and muscle explants. At the same time, HC and especially QHC bound cells in vitro and ex vivo in a fine dotted manner, as evidenced by confocal microscopy. Such a pattern of hydrophobic derivatives distribution provides the possibility to develop mucoadhesive drug delivery systems with increased local drug release and improved chitosan biodegradation.
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Year
Volume
23
Pages
103 - 113
Physical description
Contributors
  • Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  • Institute of Bioengineering, Research Centre of Biotechnology of the Russian Academy of Sciences
  • Institute of Bioengineering, Research Centre of Biotechnology of the Russian Academy of Sciences
  • Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  • Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
  • Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, esvir@ibch.ru
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article
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bwmeta1.element.psjd-7cfa678c-cb4f-4b90-8fc0-f6bbbb092e34
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