ANXIOLYTIC-LIKE ACTIVITY OF PZ-1433, A NOVEL ARYLSULFONAMIDE DERIVATIVE OF ARYLOXY(PROPYL)PIPERIDINE, IN RODENTS

• Authors: Anna PARTYKA
• Languages of publication: EN EO

Abstracts

EN

A novel arylsulfonamide derivative of aryloxy(propyl)piperidine PZ-1433, has been proved to possess a preclinical activity profile appropriate for the treatment of depression and memory impairments. In the present study its pharmacological activity toward anxiety symptoms as well as its anxiolytic properties have been examined in mouse and rat models. PZ-1433 significantly increased the number of punished crossings and decreased the number of buried marbles in two tests conducted in mice. Moreover, PZ-1433 evoked anxiolytic-like activity in “conditional” anxiety paradigm in rats, meaningly increasing the number of accepted shocks in the Vogel conflict drinking test. However, it did not produce a significant anxiolytic-like effect in “unconditional” anxiety model, i.e. the elevated plus-maze test. From these results, it is likely that direct antagonism toward serotonin 5-HT7 receptors may be involved in the anxiolytic action of PZ-1433. However, in vitro detected inhibition of serotonin transporter evoked by PZ-1433, might also contribute to this effect.

Keywords

EN

anxiety; mice; miceanxiety; rats; serotonin 5-HT7 receptor

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Journal: Medicina Internacia Revuo
• Year: 2018
• Volume: 28
• Issue: 110
• Pages: 35-46

Contributors

author

Anna PARTYKA

• 1 Jagiellonian University Medical College, Department of Clinical Pharmacy, Medyczna 9, 30-688 Kraków 2 Jagiellonian University Medical College, Department of Medical Chemistry, Medyczna 9, 30-688 Kraków,

• Document Type: article