PL EN


Preferences help
enabled [disable] Abstract
Number of results
2018 | 28 | 110 | 35-46
Article title

ANXIOLYTIC-LIKE ACTIVITY OF PZ-1433, A NOVEL ARYLSULFONAMIDE DERIVATIVE OF ARYLOXY(PROPYL)PIPERIDINE, IN RODENTS

Authors
Content
Title variants
Languages of publication
EN EO
Abstracts
EN
A novel arylsulfonamide derivative of aryloxy(propyl)piperidine PZ-1433, has been proved to possess a preclinical activity profile appropriate for the treatment of depression and memory impairments. In the present study its pharmacological activity toward anxiety symptoms as well as its anxiolytic properties have been examined in mouse and rat models. PZ-1433 significantly increased the number of punished crossings and decreased the number of buried marbles in two tests conducted in mice. Moreover, PZ-1433 evoked anxiolytic-like activity in “conditional” anxiety paradigm in rats, meaningly increasing the number of accepted shocks in the Vogel conflict drinking test. However, it did not produce a significant anxiolytic-like effect in “unconditional” anxiety model, i.e. the elevated plus-maze test. From these results, it is likely that direct antagonism toward serotonin 5-HT7 receptors may be involved in the anxiolytic action of PZ-1433. However, in vitro detected inhibition of serotonin transporter evoked by PZ-1433, might also contribute to this effect.
Publisher

Year
Volume
28
Issue
110
Pages
35-46
Physical description
Contributors
author
  • 1 Jagiellonian University Medical College, Department of Clinical Pharmacy, Medyczna 9, 30-688 Kraków 2 Jagiellonian University Medical College, Department of Medical Chemistry, Medyczna 9, 30-688 Kraków, mfpartyk@cyf-kr.edu.pl
References
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-7751f567-971c-4778-921c-f4cf39a5b6fd
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.