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2021 | 151 | 110-122
Article title

Gewald reaction for the synthesis of benzo[4,5]-thieno[2,3-d]pyrimidin-4(3H)-one derivatives and it’s antimicrobial study

Content
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EN
Abstracts
EN
A variety of schiff base of 3-amino-2,7-dimethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one have been synthesized using novel and yield efficient protocol i.e., Gewald condensation reaction by four step processes. The characterization of synthesized diverse molecules was characterized by various spectroscopic methods such as IR, Mass, and NMR. The hybrids of thieno-pyrimidines were utilized to check their efficiency as anti-microbial activity against various Gram-positive (S. aureus, S. pyogenes, MRSA- multi-resistance S. aureus) and Gram negative (E. coli, P. aeruginosa, Klebsiella pneumonia) bacteria, using five anti-microbial agents as reference standard. It was found that 4a (anti-fungal agent) and 4e (anti-bacterial agent) shown best efficiency and which can lead in the area of medicinal field.
Year
Volume
151
Pages
110-122
Physical description
Contributors
  • Department of Chemistry, Maharshi Dayanand Science College (Affiliated to Bhakta Kavi Narsinh Mehta University), Porbandar - 360575, India
author
  • Department of Chemistry, Maharshi Dayanand Science College (Affiliated to Bhakta Kavi Narsinh Mehta University), Porbandar - 360575, India
  • Department of Chemistry, Maharshi Dayanand Science College (Affiliated to Bhakta Kavi Narsinh Mehta University), Porbandar - 360575, India
References
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-769cbc14-a280-4882-a344-b5d9540f5bfd
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