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2019 | 132 | 264-269
Article title

Synthesis and characterization of novel 2-oxo-4-((4-(3-oxomorpholino)phenyl)amino)-2H-chromene-3-carbaldehyde derivatives

Content
Title variants
Languages of publication
EN
Abstracts
EN
A highly functionalized heterocyclic library were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel synthetic rout involves nucleophilic substitution reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with 4-(4-aminophenyl) morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. All the synthesized compound of libraries characterized using 1H NMR, Mass, and IR spectroscopic technique. Also all compound screened for antimicrobial activity against standard drugs.
Year
Volume
132
Pages
264-269
Physical description
Contributors
  • SMT. J.A. Patel Mahila College, Patel Kanya Chhatralaya Campus, B/H New bus station, Morbi - 363641, Gujarat, India
  • School of Science, RK University, Kasturbadham, Rajkot Gujarat, India
author
  • SMT. J.A. Patel Mahila College, Patel Kanya Chhatralaya Campus, B/H New bus station, Morbi - 363641, Gujarat, India
  • Shree H.N. Shukla College of Science, B/H Marketing yard, Bhichari, Rajkot, Gujarat, India
References
  • [1] Perrella, F. W.; Chen, S. F.; Behrens, D. L.; Kaltenbach, R. F.; Seitz, S. P. J. Med. Chem. 1994, 37, 2232
  • [2] Bauvois, B.; Puiffe, M. L.; Bongui, J. B.; Paillat, S.; Monneret, C.; Dauzonne, D. J. Med. Chem. 2003, 46, 3900
  • [3] Vasselin, A. D.; Westwell, A. D. ; Matthews, C. S.; Bradshaw, T. D.; Stevens, M. F. G. J. Med. Chem. 2006, 49, 3973
  • [4] Huang, X.; Liu, T.; Gu, J.; Luo, X.; Ji, R.; Cao, Y.; Xue, H. J.; Wong, T. F.; Wong, B. L.; Pei, G.; Jiang, H.; Chen, K. J. Med. Chem. 2001, 44, 1883
  • [5] Dauzonne, D.; Martinez, L. Tetra. Lett. 1995, 36, 1845
Document Type
short_communication
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-766228fc-8546-459b-a01f-c576c86d899f
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