BIOMATERIALS BASED ON CHITOSAN AND ITS DERIVATIVES TO PREVENT ADHESION FORMATION

• Authors: Mariya Konovalova , Daria Tsaregorodtseva , Elena Svirshchevskaya
• Languages of publication: EN

Abstracts

EN

An increase in the number and volume of surgical interventions leads to an increase in the frequency of postoperative adhesions. The development of the adhesion process in the abdominal cavity causes pain, a decrease in the quality of life of patients, a violation of the reproductive function of women as well as acute adhesion intestinal obstruction. Recently, polymer biomaterials, including those based on chitosan, have been widely used for the prevention of adhesions. Due to their biocompatibility and biodegradation ability, they do not require repeated operations to extract the material. It is believed that these materials act as barriers, physically separating the damaged surfaces. The molecular mechanism of their action is still poorly understood. In this review, the main mechanisms of adhesion formation, as well as ways to prevent them with the help of materials based on chitosan and its derivatives, are discussed

Keywords

EN

biomaterials; chitosan; derivatives of chitosan; polymers; prevention of adhesions

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2021
• Volume: 26
• Pages: 11-22

Contributors

author

Mariya Konovalova

• Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

author

Daria Tsaregorodtseva

• I.M. Sechenov First Moscow State Medical University

author

Elena Svirshchevskaya

• Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

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• Document Type: review