Rola przysadkowej i pozaprzysadkowej prolaktyny w rozrodzie i onkologii

• Authors: Władysław Skałba , Magdalena Lemm , Andrzej Witek

Title variants

EN

The role of pituitary and extrapituitary prolactin in reproduction and oncology

• Languages of publication: PL

Abstracts

PL

Prolaktyna (PRL) działa w organizmie człowieka jako hormon wydzielany do krwi i jako cytokina. W pracy, po krótkim przedstawieniu struktury PRL i jej receptora, skoncentrowano się na lokalnym wydzielaniu hormonu przez endometrium i komórki jajnika. Omówiono dostępne informacje na temat auto- i parakrynnego działania hormonu w endometrium i jajniku. Zwrócono uwagę na rolę PRL w rakach endometrium i jajnika oraz na kliniczne aspekty dotyczące diagnostyki i nowych możliwości terapeutycznych w tych nowotworach, wynikające z badań nad osią PRL–PRLR. W zakończeniu zasugerowano, iż wiele interesujących problemów, ważnych z punktu widzenia patologii i kliniki obu nowotworów, nie zostało jeszcze odkrytych, stanowiąc wyzwanie dla przyszłych badań.

EN

Prolactin (PRL) acts in the body as a hormone secreted into the blood and as a cytokine. In this review after a brief presentation of the structure of PRL and its receptor, we have focused on local hormone secretion by endometrial and ovarian cancer cells. We have discussed the available information about the autocrine/paracrine hormone signaling pathway in the endometrium and ovary. More attention was focused on the role of PRL in endometrial and ovarian cancers. What is more, the clinical aspects related to the diagnosis and new therapeutic options in these tumors are described. At the end, we have included the suggestion that a number of interesting and important problems of both cancers concerning the pathology and treatment have not yet been discovered, which is a challenge for future research.

Keywords

EN

endometrial carcinoma; ovarian cancer; prolactin; prolaktyna; rak endometrium; rak jajnika

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2016
• Volume: 70
• Pages: 46–50

Contributors

author

Władysław Skałba

• Władysław Skałba, Katedra i Klinika Ginekologii i Położnictwa SUM w Katowicach, ul. Medyków 14, tel. [phone]

author

Magdalena Lemm

• Katedra i Klinika Ginekologii i Położnictwa Śląskiego Uniwersytetu Medycznego w Katowicach, Klinika Endokrynologii Ginekologicznej Śląskiego Uniwersytetu Medycznego w Katowicach

author

Andrzej Witek

• Katedra i Klinika Ginekologii i Położnictwa Śląskiego Uniwersytetu Medycznego w Katowicach

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• Document Type: article