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Journal
2014 | 4 | 4 | A148-A154
Article title

Administration of liposomal doxorubicin in patients with metastatic breast cancer and significant concomitant cardiovascular conditions

Content
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EN
Abstracts
EN
A frequent dilemma faced by an oncologist about to take decision on a chemotherapeutic regime for patients with metastatic breast cancer is how to maintain balance between the expected treatment efficacy and predictable adverse events. In the case of anthracyclines what is problematic is their significant cardiotoxicity, in particular with reference to patients previously treated with them as part of adjuvant therapy. A relatively new method is replacement of conventional doxorubicin with its non-pegylated form, encapsulated in liposomes, which is capable of minimizing the side effects without compromising its therapeutic index. The present article discusses three cases of patients treated with non-pegylated liposomal doxorubicin (NPLD) as first-line chemotherapy administered for metastatic breast cancer. In all three cases considerable clinical improvement was observed, involving remission of pathological lesions and good quality of life.
Discipline
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Journal
Year
Volume
4
Issue
4
Pages
A148-A154
Physical description
Contributors
  • Regional Oncology Centre in Lodz, Department of Chemotherapy, Copernicus Memorial Hospital in Lodz
References
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  • Batist G, Remakrishnan G, Rao CS et al. Reduced cardiotoxity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin with cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer. J Clin Oncol 2001; 19: 1444-1454.
  • Batist G, Harris L, Azarina N et al. Improved anti-tumor response rate with decreased cardiotoxity of non-pegylated liposomal doxorubicin compared with conventional doxorubicin in first-line treatment of metastatic breast cancer in patients who haved received prior adjuvant doxorubicin: results of a retrospective analysys. Anticancer Drugs 2006; 17: 587-595.
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-7485a800-c30d-453a-924c-c4717bcbae72
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