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2019 | 73 | 19–24
Article title

Limfocyty Th22, Th17.1, Tc17, Tfh i NKTfh w patogenezie stwardnienia rozsianego

Title variants
Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in pathogenesis of multiple sclerosis
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Multiple sclerosis (MS) is the most common inflammatory-demyelinating disease, its morbidity varies between 2 per 100 000 inhabitants in sub-Saharan Africa to 100 per 100 000 inhabitants in Europe and North America. Despite the unquestionable progress in medicine, MS is still incurable and all that can be done for a patient is to struggle to slow down the inevitable progress of the disease, which eventually will cause disability. Recognizing the detailed immunopathogenesis of MS is probably the only chance for fully effective treatment. Most of the immunological studies of the previous decades focused on the classic sub-populations of T lymphocytes. This review is focused, however, on novel sub-populations – Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in the pathogenesis of MS.
Stwardnienie rozsiane (multiple sclerosis – MS) jest najczęstszą chorobą zapalno-demielinizacyjną. Chorobowość wynosi od około 2/100 000 w okolicach równika do około 100/100 000 w Europie i Ameryce Północnej. Pomimo znacznego postępu medycyny, jaki dokonał się w ostatnich dziesięcioleciach, schorzenie to cały czas pozostaje nieuleczalne. Jedyną możliwością jest walka o spowolnienie nieuchronnego postępu choroby, który w końcu doprowadzi do niepełnosprawności pacjenta. Z tego względu ważne jest dokładne poznanie immunopatogenezy MS. Prowadzone dotychczas badania skupiały się na klasycznych subpopulacjach komórek T. W niniejszym artykule przyjrzymy się stanowi badań i dostępnej wiedzy na temat udziału „nowych” subpopulacji komórek T, tj. limfocytów Th22, Th17.1, Tc17, Tfh, NKTfh, w patogenezie MS.

Physical description
  • Katedra i Zakład Immunologii Klinicznej, Uniwersytet Medyczny w Lublinie
  • Katedra i Zakład Immunologii Klinicznej, Uniwersytet Medyczny w Lublinie
  • Katedra i Zakład Immunologii Klinicznej, Uniwersytet Medyczny w Lublinie
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