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A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
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181-191
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- SMT. Jayaben Ambalal Patel Mahila College, Morbi - 363641, Gujarat, India
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- Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
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- Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
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- Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
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- Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
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- Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
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- Tirt Nidatt. Rao College, Rajkot – 360005, Gujarat, India
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- Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
author
- SMT. Jayaben Ambalal Patel Mahila College, Morbi - 363641, Gujarat, India
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article
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bwmeta1.element.psjd-71bc5526-dc5c-4cde-b578-bab8ae7aeabf