Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity

• Authors: Vijay D. Chodvadiya , Kaushik D. Pambhar , Nilesh D. Parmar , Ashish P. Dhamsaniya , Shahrukh khan A. Safi , Pratiksha V. Chhatbar , Hemal N. Ram , Ranjan C. Khunt , P. K. Patel
• Languages of publication: EN

Abstracts

EN

A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.

Keywords

EN

Anti-microbial agents; Desulfitative displacement; N-methyl indole; S-methyl

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World Scientific News
• Year: 2019
• Volume: 120
• Issue: 2
• Pages: 181-191

Contributors

author

Vijay D. Chodvadiya

• SMT. Jayaben Ambalal Patel Mahila College, Morbi - 363641, Gujarat, India

author

Kaushik D. Pambhar

• Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India

author

Nilesh D. Parmar

• Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India

author

Ashish P. Dhamsaniya

• Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India

author

Shahrukh khan A. Safi

• Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India

author

Pratiksha V. Chhatbar

• Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India

author

Hemal N. Ram

• Tirt Nidatt. Rao College, Rajkot – 360005, Gujarat, India

author

Ranjan C. Khunt

• Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India

author

P. K. Patel

• SMT. Jayaben Ambalal Patel Mahila College, Morbi - 363641, Gujarat, India

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• Document Type: article