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2019 | 120 | 2 | 181-191
Article title

Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity

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EN
Abstracts
EN
A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
Year
Volume
120
Issue
2
Pages
181-191
Physical description
Contributors
  • SMT. Jayaben Ambalal Patel Mahila College, Morbi - 363641, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
author
  • Tirt Nidatt. Rao College, Rajkot – 360005, Gujarat, India
  • Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
author
  • SMT. Jayaben Ambalal Patel Mahila College, Morbi - 363641, Gujarat, India
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Document Type
article
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Identifiers
YADDA identifier
bwmeta1.element.psjd-71bc5526-dc5c-4cde-b578-bab8ae7aeabf
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