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2021 | 26 | 71-79

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The aim of this research was to develop a bioadhesive film based on benzydamine hydrochloride incorporated into natural bioadhesive polymers with different quantities of chitosan and guar gum but utilising a plasticiser. The obtained gels were deaerated by sonification, formed and evaporated by hot air drying; then, the properties were evaluated. Guar gum had a great influence on mechanical properties of the films – dynamic viscosity, texture, elasticity, stretching robustness, swelling and blur time. The formulations were used to obtain mucoadhesive films containing 0.3% benzydamine hydrochloride; they were tested for the release of the model drug. The amount of chitosan added to the formulation reduced the quantity of released substance and slowed down the release. Fouriertransform infrared spectroscopy did not reveal the creation of new chemical structures. In conclusion, the ratio of chitosan to guar gum in the medium impacts the mechanical properties and release parameters of the drug. These findings should enable researchers to match the parameter values to receive the most beneficial therapeutic outcome.






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  • Department of Drugs Form Technology. Faculty of Pharmacy. Wroclaw Medical University


  • Sharpe L., Daily A., Horava S., Peppas N., (2014) Therapeutic applications of hydrogels in oral drug delivery. Expert Opin Drug Deliv.,11, 901–915. DOI:10.151 7/17425247.2014.902047
  • Chaves P., Frank L.A., Frank A.G., Pohlmann A.R., Guterres S.S., Beck R., (2018) Mucoadhesive Properties of Eudragit®RS100, Eudragit®S100, and Poly(ε-caprolactone) Nanocapsules: Influence of the Vehicle and the Mucosal Surface.; AAPS PharmSciTech. 19, 1637–1646. DOI:10.1208/s12249-018-0968-5
  • Younes I., Rinaudo M.,(2015) Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications. Marine Drugs, 2015, 13, 1133–1174. DOI:10.3390/md13031133
  • Saad M. Ahsan, Mathai T., Kranthi K. Reddy, Sujata Gopal Sooraparaju , Amit Asthana, Ira Bhatnagar (2017) Chitosan as biomaterial in drug delivery and tissue engineering.; Int J Biol Macromol., 110, 97–109. DOI: 10.1016/j.ijbiomac.2017.08.140
  • Singh M., Tiwary A.K., Kaur G., (2010) Investigations on interpolymer complexes of cationic guar gum and xanthan gum for formulation of bioadhesive films. Res Pharm Sci. 5, 79–87.
  • Sanghai P., Nandgude T. and Poddar S., (2016) : Formulation of Bilayer Benzydamine HCl Patch Targeted For Gingivitis; Journal of Drug Deliv. Article ID 7598398, 1–9. DOI.org/10.1155/2016/7598398
  • Roopashri G., Jayanthi K. and Guruprasad R., (2011). Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail. Contemp Clin Den . 2, 8–12. DOI: 10.4103/0976-237X.79292.
  • Farmakopea Polska XI. Polska XI. Urząd Rejestracji Produktów Leczniczych, Wyrobów medycznych i Produktów Biobójczych, (2017), PTF, Warszawa, Polska, 491–494.
  • Vinklárková L., Masteiková R., Vetchý D., Doležel P., Bernatonienė J.(2015) Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain. BioMed Research International, Article ID 892671, 1–11. DOI.org/10.1155/2015/892671
  • Momoha F., Boatenga J., Richardson S., Chowdhry B., Mitchel J., (2015) Development and functional characterization of alginate dressing as potential protein. Int. J. Biol. Macromol. 81, 137–150 DOI.org/10.1016/j.ijbiomac.2015.07.037
  • Farmakopea Polska XI. Urząd Rejestracji Produktów Leczniczych, Wyrobów medycznych i Produktów Biobójczych. PTF, Warszawa, Polska, 2017, 429–434.
  • Pippi R., Santoro M., Cafolla A., (2017) The Use of a Chitosan-Derived Hemostatic Agent for Postextraction Bleeding Control in Patients on Antiplatelet Treatment. J Oral Maxillofac Surg.,75, 1118–1123. DOI: 10.1016/j.joms.2017.01.005.
  • Mclean D., Agarwal V. Stack K., Horne J. Richardson D.E., (2011) Synthesis of guar gum-graft-poly(acrylamide-codiallyldimethylammonium chloride) and its application in the pulp and paper industry. BioResources., 2011, 6, 4168.

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