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Number of results
2021 | 26 | 71-79

Article title

FORMULATION AND CHARACTERISATION OF MUCOADHESIVE DENTAL APPLICATIONS CONTAINING BENZYDAMINE HYDROCHLORIDE

Content

Title variants

Languages of publication

EN

Abstracts

EN
The aim of this research was to develop a bioadhesive film based on benzydamine hydrochloride incorporated into natural bioadhesive polymers with different quantities of chitosan and guar gum but utilising a plasticiser. The obtained gels were deaerated by sonification, formed and evaporated by hot air drying; then, the properties were evaluated. Guar gum had a great influence on mechanical properties of the films – dynamic viscosity, texture, elasticity, stretching robustness, swelling and blur time. The formulations were used to obtain mucoadhesive films containing 0.3% benzydamine hydrochloride; they were tested for the release of the model drug. The amount of chitosan added to the formulation reduced the quantity of released substance and slowed down the release. Fouriertransform infrared spectroscopy did not reveal the creation of new chemical structures. In conclusion, the ratio of chitosan to guar gum in the medium impacts the mechanical properties and release parameters of the drug. These findings should enable researchers to match the parameter values to receive the most beneficial therapeutic outcome.

Year

Volume

26

Pages

71-79

Physical description

Contributors

  • Department of Drugs Form Technology. Faculty of Pharmacy. Wroclaw Medical University

References

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Document Type

article

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.psjd-7033e898-3890-43b8-98dc-994b9ed3571e
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