Psychotic symptoms due to topiramate

• Authors: Gülay Oğuz , Mükerrem Güven , Saime Çağlı , Sedat Batmaz

Title variants

EN

Objawy psychotyczne wywołane stosowaniem topiramatu

• Languages of publication: EN PL

Abstracts

EN

Topiramate is an antiepileptic drug prescribed in the treatment of numerous psychiatric disorders and in epilepsy. Topiramate exerts its antiepileptic effect through different mechanisms, such as by the blockage of sodium channels, increasing GABAergic neurotransmission, antagonizing excitatory amino acid receptors (glutamate) or blocking calcium channels. Its prescription in psychiatric diseases has increased in recent years and psychotic symptom development due to the usage of topiramate has been observed in some studies. Therefore, it is essential to evaluate the patient for psychotic symptoms while using topiramate. This article presents a case of a 37-year-old woman who developed depression, anxiety and auditory hallucinations during the treatment with 150 mg of topiramate. After stopping topiramate, 5 mg of olanzapine bid was started and the symptoms gradually decreased and finally disappeared.

PL

Topiramat to lek przeciwdrgawkowy przepisywany w leczeniu wielu zaburzeń psychicznych i padaczce. Mechanizm działania przeciwdrgawkowego jest wielokierunkowy – np. lek ten blokuje kanały sodowe, stymuluje neurotransmisję w układzie GABA-ergicznym, antagonizuje receptory dla pobudzających aminokwasów (glutaminian) oraz blokuje kanały wapniowe. Jakkolwiek w ostatnich latach topiramat przepisywany jest coraz częściej w leczeniu zaburzeń psychicznych, to jednak w kilku badaniach zgłaszano występowanie objawów psychotycznych w następstwie jego stosowania. Z tego względu szczególnie ważna jest ocena pacjentów stosujących ten lek pod kątem występowania objawów psychotycznych. Autorzy przedstawiają przypadek 37-letniej pacjentki, u której w związku z leczeniem z użyciem 150 mg topiramatu rozwinęły się depresja, zaburzenia lękowe i omamy słuchowe. Po odstawieniu topiramatu zalecono stosowanie 5 mg olanzapiny dwa razy dziennie. Objawy stopniowo zanikały, aż do całkowitego ustąpienia.

Keywords

EN

auditory hallucinations; objawy psychotyczne; omamy słuchowe; psychotic symptoms; topiramat; topiramate

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Psychiatria i Psychologia Kliniczna
• Year: 2015
• Volume: 15
• Issue: 1
• Pages: 38–40

Contributors

author

Gülay Oğuz

• Department of Psychology, Faculty of Science and Letters, Canik Başarı University, Samsun, Turkey

author

Mükerrem Güven

• Department of Psychiatry, Akdeniz University, School of Medicine, Antalya, Turkey

author

Saime Çağlı

• Private Practice, Samsun, Turkey

author

Sedat Batmaz

• Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Tokat, Turkey, tel.: [phone] – 1290, fax: [phone]

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• Document Type: review