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2018 | 91 | 99-110
Article title

Investigation of phytochemicals and in vivo antidiabetic evaluation of leaves and bark of Engelhardtia colebrookiana Lindl.

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EN
Abstracts
EN
Diabetes mellitus is a complex metabolic disorder resulting from either insulin insufficiency or insulin dysfunction. Diabetes mellitus affects most of the people in both developed and developing countries. The treatment of diabetes with synthetic drugs is costly and chances of side effects are high. Phytomedicine has been used since ancient times in various parts of the world where access to modern medicine is limited. Present study was designed to check the anti-diabetic activity of methanolic extract of Engelhardtia colebrookiana L. locally known as samma or samna on Alloxan induced diabetic rabbits. Animals were divided into five groups. Group I: In this group rabbits were considered as normal control. Group II: In this group rabbits was considered as diabetic control. Group III: In this group rabbits were given by Glucophage. Group IV: In this group rabbits were given by oral dose of 1g of methanolic extract of Engelhardtia colebrookiana’s bark per day. Group V: In this group rabbits were given oral dose of 1g of methanolic extract of Engelhardtia colebrookiana’s leaves per day. The leaves extract significantly reduces the blood glucose level and body weight along with these it was found very effective in improving serum insulin level as compared to other groups and no side effect was observed in the rabbits during treatment.
Discipline
Year
Volume
91
Pages
99-110
Physical description
Contributors
  • Department of Botany (Bhimber Campus), Mirpur University of Science and Technology (MUST), Mirpur - 10250 (AJK), Pakistan
  • Department of Botany (Bhimber Campus), Mirpur University of Science and Technology (MUST), Mirpur - 10250 (AJK), Pakistan
  • Department of Botany (Bhimber Campus), Mirpur University of Science and Technology (MUST), Mirpur - 10250 (AJK), Pakistan
  • Department of Botany (Bhimber Campus), Mirpur University of Science and Technology (MUST), Mirpur - 10250 (AJK), Pakistan
References
  • [1] Aiyelaagbe, O.O. and P.M. Osamudiamen. 2009. Phytochemical screening for active compounds in Mangifera indica leaves from Ibadan, Oyo State. Plant Sci. Res. 2(1): 11-13.
  • [2] Akhtar, M.S. 1992. Hypoglycaemic activities of some indigenous medicinal plants traditionally used as antidiabetic drugs. J. Pak. Med. Assoc. 11(2): 271-277.
  • [3] Alam, M.A. and M.E. Haque. 2006. Anticociceptive effect of the crude ethanolic extract of Crateva nurvala buch on mice. Bangl. J. Vet. Med. 4: 65–8.
  • [4] Cousens, G. 2008. There is a cure for diabetes: The Tree of Life 21 day program. California: North Atlantic Books, 191-192.
  • [5] Harborne, J.B. 1991. Phytochemical Methods, A Guide to Modern Techniques of Plant Analysis, Chapman and Hall, London, pp. 58, 74, 84, 88, 120, 126, 176-201.
  • [6] Harrison, L.C. and M.C. Honeyman. 1999. Cow's milk and type 1 diabetes: the real debate is about mucosal immune function. Diabetes, 48: 1501-1507.
  • [7] Kavishankar, G.B, N. Lakshidevi, S.M. Murthy, H.S. Prakash and S.R. Niranjana. 2011. Diabetes and medicinal plants: an overview. Int. J. Pharm. Biomed. Sci. 2(3): 65-80.
  • [8] Kumar, P.J. and M. Clark. 2002. Textbook of Clinical Medicine. Pub: Saunders (London), 1099-1121.
  • [9] Okwu, D.E. and C. Josiah. 2006. Evaluation of the chemical composition of two Nigerian medicinal plants. Afr. J. Biotechnol. 5(4): 357-361.
  • [10] Patel, D.K., S. K. Prasad, R. Kumar and S. Hemalatha. 2012. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pacific J. Tropical Biomed. 320-330.
  • [11] Raman, A. and C. Lau. 1996. Anti-diabetic properties and phytochemistry of Momordica charantia L.(Cucurbitaceae). Phytomedicine, 2: 349-362.
  • [12] Shaw, J.E., R.A. Sicree and P.Z. Zimment. 2010. Global estimate of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 87(1):4-14. induced diabetic rats. Asian Pac. J. Trop. Biomed. 1 (4): 316-322.
  • [13] Sofowora, A. 2006. Medicinal Plants and Traditional Medicines in Africa. 2nd Ed., Spectrum Books Ltd., Ibadon, Nigeria. Pp. 151-153, 209-214.
  • [14] Wadood, N., M. Nisar, A. Rashid, A. Wadood, G. Nawab and Khan. 2007. Effect of a compound recipe (medicinal plants) onserum insulin levels of alloxan induced diabetic rabbits. J. Ayub Med. Coll. Abbott. 19 (1).
  • [15] Wild, S., G, Roglic and A. Green. 2004. Globsal prevalence of diabetes mellitus; Estimates for year 2000 and projections for 2030. Diabetes Care, 27(5), 1047-1053.
  • [16] Sudhir K. Uniyal, Vinayak Badoni & O. P. Sati. A New Piscicidal Flavonoid Glycoside from Engelhardtia colebrookiana. International Journal of Pharmacognosy Volume 30, 1992, Issue 3, Pages 209-212, 1991
  • [17] G. C. S. Negi, S. P. Singh. Leaf growth pattern in evergreen and deciduous species of the Central Himalaya, India. International Journal of Biometeorology December 1992, Volume 36, Issue 4, pp 233–2
  • [18] Singh JS, Singh SP (1987) Forest vegetation of the Himalaya. Bot Rev 52: 80–192
  • [19] Ralhan PK, Khanna RK, Singh SP, Singh JS (1985) Phenological characteristics of the tree layer of Kumaun Himalayan forests. Vegetatio 60: 90–101
Document Type
article
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YADDA identifier
bwmeta1.element.psjd-6efcfcc4-5a41-4c54-bf01-34864533b384
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