Myocardial dysfunction related to trastuzumab therapy – is effective treatment always possible?

• Authors: Sebastian Szmit , Łukasz Kownacki , Adam Torbicki
• Languages of publication: EN

Abstracts

EN

Left ventricle systolic dysfunction manifesting during trastuzumab treatment is defined as cardiotoxicity type II. It is characterized by full reversibility after discontinuation of trastuzumab and cardiological pharmacological treatment. In a group of patients, however, systolic cardiac function does not fully recover. The reasons of this unfavorable prognosis are subject of heated discussion.

Keywords

EN

breast cancer; cardiotoxicity type II; trastuzumab

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2014
• Volume: 4
• Issue: 2
• Pages: A62-68

Contributors

author

Sebastian Szmit

• Department of Pulmonary Circulation and Tromboembolic Diseases, Centre of Postgraduate Medical Education, European Health Centre Otwock

author

Łukasz Kownacki

• Department of Radiology, European Health Centre Otwock

author

Adam Torbicki

• Department of Pulmonary Circulation and Tromboembolic Diseases, Centre of Postgraduate Medical Education, European Health Centre Otwock

References

• Ewer MS, Lippman SM. Type II Chemotherapy-Related Cardiac Dysfunction: Time to Recognize a New Entity. J Clin Oncol 2005; 23: 2900-2902.
• Ewer MS, Vooletich MT, Durand JB et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol 2005; 23(31): 7820-6.
• Seidman A, Hudis C, Pierri MK et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 2002; 20: 1215-1221.
• Ewer MS, Vooletich MT, Durand JB et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol 2005; 23(31): 7820-6.
• Perez EA, Suman VJ, Davidson NE et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol 2008; 26(8): 1231-8.
• Tan-Chiu E, Yothers G, Romond E et al. Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol. 2005; 23(31): 7811-9.
• Suter TM, Procter M, van Veldhuisen DJ et al. Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol 2007; 25(25): 3859-65.
• Procter M, Suter TM, de Azambuja E et al. Longer-Term Assessment of Trastuzumab-Related Cardiac Adverse Events in the Herceptin Adjuvant (HERA) Trial. J Clin Oncol 2010; 28: 3422-3428.
• Russell SD, Blackwell KL, Lawrence J et al. Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamidefollowed by trastuzumab adjuvant therapy:a combined review of cardiac data from the National Surgical Adjuvantbreast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 clinical trials. J Clin Oncol 2010; 28(21): 3416-21.
• Szmit S, Kurzyna M, Glówczynska R et al. Manageability of acute severe heart failure complicated with left ventricular thrombosis during therapy for breast cancer. Int Heart J 2010; 51(2): 141-5.
• Cardinale D, Colombo A, Torrisi R et al. Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin i evaluation. J Clin Oncol 2010; 28: 3910-3916.
• Curigliano G, Cardinale D, Suter T et al. on behalf of the ESMO Guidelines Working Group. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines Annals of Oncology 23 (Supplement 7): vii155–vii166, 2012.
• Steingart RM, Yadav N, Manrique C et al. Cancer survivorship: cardiotoxic therapy in the adult cancer patient; cardiac outcomes with recommendations for patient management. Semin Oncol. 2013; 40(6): 690-708.
• Druck MN, Gulenchyn KY, Evans WK et al. Radionuclide angiography and endomyocardial biopsy in the assessment of doxorubicin cardiotoxicity. Cancer 1984; 53(8): 1667-74.
• Tarantini L, Cioffi G, Gori S, et al; Italian Cardio-Oncologic Network. Trastuzumab adjuvant chemotherapy and cardiotoxicity in real-world women with breast cancer. J Card Fail 2012; 18(2): 113-9.
• Fallah-Rad N, Walker JR, Wassef A et al. The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapy. J Am Coll Cardiol 2011; 57(22): 2263-70.
• Negishi K, Negishi T, Haluska BA et al. Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection. Eur Heart J Cardiovasc Imaging 2014; 15(3): 324-31

• Document Type: report