ASSESSMENT OF PHARMACEUTICAL PROPERTIES OF GYNAECOLOGICAL HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 23 cm to 26 cm and at 2:1 ratio from 25 cm to 29 cm. Gels with addition 20-25% poloxamer 407 containing lactic acid complexed with chitosan and 5-25% content of glycerol reveal pH from 4.25 to 4.98 for 1:1 and from 3.60 to 4.45 for 2:1. The investigations showed that the addition of a thermosensitive polymer increases the adhesive properties of the investigated gels, but at the same time it increases their pH. The addition of glycerol or 1,2-propylene glycol reduces the pH and maintains high adhesion. The use of hydrofilizing substances allowed to obtain physiological range pH gynaecological gels.

Keywords

EN

1; 2- propylene glycol; anti-inflammatory drugs.; glycerol; lactic acid complexed with chitosan; thermosensitive polymer - poloxamer 407; vaginal infections

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2012
• Volume: 17
• Pages: 117 - 124

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw

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• Document Type: article