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2012 | 17 | 117 - 124
Article title

ASSESSMENT OF PHARMACEUTICAL PROPERTIES OF GYNAECOLOGICAL HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

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Abstracts
EN
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 23 cm to 26 cm and at 2:1 ratio from 25 cm to 29 cm. Gels with addition 20-25% poloxamer 407 containing lactic acid complexed with chitosan and 5-25% content of glycerol reveal pH from 4.25 to 4.98 for 1:1 and from 3.60 to 4.45 for 2:1. The investigations showed that the addition of a thermosensitive polymer increases the adhesive properties of the investigated gels, but at the same time it increases their pH. The addition of glycerol or 1,2-propylene glycol reduces the pH and maintains high adhesion. The use of hydrofilizing substances allowed to obtain physiological range pH gynaecological gels.
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Year
Volume
17
Pages
117 - 124
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References
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article
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bwmeta1.element.psjd-6c429978-1234-458f-8438-3a0092b238ca
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