INFLUENCE OF POLOXAMER 407 ON THE PROPERTIES GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Thermosensitive hydrophilic powders passing in gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 8:1 reveal pH ranged from 4.00 to 4.91 and 2.56 to 3.42. Rheological studies demonstrated that the investigated thermosensitive gels obtained from powders have the dynamic viscosity in the ranged from 269 mPa*s to 579 mPa*s for the 1:1 stoichiometric ratio and in the range from 220 mPa*s to 530 mPa*s for 8:1 ratio. As a result of the research preparations with different pH values including the physiological range were obtained. The thermosensitive gels obtained from the thermosensitive powders were characterized by the specific dynamic viscosity. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.

Keywords

EN

anti-inflammatory drugs; lactic acid complexed with chitosan; physiological environment of vagina; thermosensitive hydrophilic powders; vaginal infections; vaginal mucosa

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2016
• Volume: 21
• Pages: 154-159

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy, The “Silesian Piasts” memorial Medical University of Wroclaw, Borowska 211A Street, 50-556 Wrocław, Poland.

References

• [1] Schwebke JR; (2009) New Concepts in the Etiology of Bacterial Vaginosis. Curr. Infect. Dis. Rep. 11, 143 – 147. DOI: 10.1007/s11908-009-0021-7
• [2] Brandt M, Abels C, May T, Lohmann K, Schmidts – Winkler I, Hoyme UB; (2008) Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects. Eur. J. Obstet. Gynecol. Reprod. Biol. 141, 158 – 162. DOI: 10.1016/j.ejogrb.2008.07.022
• [3] Donders GGG, Larson PG, Platz – Christensen JJ, Hallen A, Meijden W, Wölner – Hanssen P; (2009) Variability in diagnosis of clue cells, lactobacillary grading and white blood cells in vaginal wet smears with conventional bright light and phase contrast microscopy. Eur. J. Obstet. Gynecol. Reprod. Biol. 145, 109 – 112. DOI: 10.1016/j.ejogrb.2009.04.012
• [4] Kubis AA, Małolepsza-Jarmołowska K; (1996) Studies on gynecological hydrophiling preparations comprising lactic acid. Part 1: Effects of lactic acid and hydrophiling agents on physical and chemical properties of methylcellulose gels. Pharmazie 51, 989 – 990.
• [5] Małolepsza-Jarmołowska K, Kubis AA; (1999) Studies on gynecological hydrophilic lactic acid preparations. Part 2: Effects of Eudragit® E-100 on properties of methylcellulose gels. Pharmazie 54, 441 – 443.
• [6] Małolepsza-Jarmołowska K, Kubis AA; (2000) Studies on gynaecological hydrophilic lactic acid preparations. Part 3: Effects of chitosan on the properties of methylcellulose gels. Pharmazie 55, 610 – 611.
• [7] Małolepsza-Jarmołowska K, Kubis AA; (2001) Studies on gynaecological hydrophilic lactic acid preparations. Part 4: Effects of polyvinyl pyrrolidone K-90 on properties of methylcellulose gels. Pharmazie 56, 160 – 162.
• [8] Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 260 – 262.
• [9] Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 6: Use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 334-336.
• [10] Małolepsza-Jarmołowska K; (2006) Studies on gynaecological hydrophilic lactic acid preparations. Part 7: Use of chitosan as lactic acid carrier in intravaginal tablets (globuli vaginales). Pharmazie 61, 780 - 782.
• [11] Małolepsza-Jarmołowska K; (2007) Studies on gynaecological hydrophilic lactic acid preparations. Part 8: Use of chitosan as lactic acid carrier in intravaginal tablets. Acta Pol. Pharm. 64, 69 - 72.
• [12] Małolepsza-Jarmołowska K; (2010) The effect of poloxamer 407 on the properties of hydrophilic gels containing lactic acid complexed with chitosan. Monograph vol. XV ed. by M. Jaworska „Progress on Chemistry and Application of Chitin and Its Derivatives“ 15, 143-148.

• Document Type: article