INFLUENCE OF A PECTIN ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Gynecological powders are designed to correct abnormal pH environments of the vagina and the stabilise the pH to the physiological state 3.5-5.0. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional pectin and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and pectin in comparison to the gels without pectin. Studies of work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentration on the value of the work of adhesion. The results obtained in the experimental studies demonstrated that it is possible to produce a preparation with optimal pharmaceutical and application properties.

Keywords

EN

anti-inflammatory drugs; hydrophilic powders; lactic acid-chitosan complex; physiological environment of vagina; vaginal infections; vaginal mucosa

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2017
• Volume: 22
• Pages: 135-142

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw, 50-556 Wrocław, Borowska 211A Street, Poland.

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• Document Type: article