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2017 | 22 | 135-142
Article title

INFLUENCE OF A PECTIN ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

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EN
Abstracts
EN
Gynecological powders are designed to correct abnormal pH environments of the vagina and the stabilise the pH to the physiological state 3.5-5.0. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional pectin and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and pectin in comparison to the gels without pectin. Studies of work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentration on the value of the work of adhesion. The results obtained in the experimental studies demonstrated that it is possible to produce a preparation with optimal pharmaceutical and application properties.
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Year
Volume
22
Pages
135-142
Physical description
Contributors
  • Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw, 50-556 Wrocław, Borowska 211A Street, Poland., katarzynamj@poczta.onet.pl
References
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  • [4] Kubis AA, Małolepsza-Jarmołowska K; (1996) Studies on gynecological hydrophiling preparations comprising lactic acid. Part 1: Effects of lactic acid and hydrophiling agents on physical and chemical properties of methylcellulose gels. Pharmazie 51, 989 – 990.
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  • [8] Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 260 – 262.
  • [9] Małolepsza-Jarmołowska K, Kubis AA, Hirnle L; (2003) Studies on gynaecological hydrophilic lactic acid preparations. Part 6: Use of Eudragit® E-100 as lactic acid carrier in intravaginal tablets. Pharmazie 58, 334-336.
  • [10] Małolepsza-Jarmołowska K; (2006) Studies on gynaecological hydrophilic lactic acid preparations. Part 7: Use of chitosan as lactic acid carrier in intravaginal tablets (globuli vaginales). Pharmazie 61, 780 - 782.
  • [11] Małolepsza-Jarmołowska K; (2007) Studies on gynaecological hydrophilic lactic acid preparations. Part 8: Use of chitosan as lactic acid carrier in intravaginal tablets. Acta Pol. Pharm. 64, 69 - 72.
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  • [13] Małolepsza-Jarmołowska K; (2014) Research of pharmaceutical properties of hydrophilic powders containing lactic acid complexed with chitosan „Progress on Chemistry and Application of Chitin and Its Derivatives“, XIX, 79-86. DOI:10.15259/PCACD.19.09
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-69146aab-78ec-401f-aab3-a91872110447
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