Design, Synthesis, Characterization and Antimicrobial Screening of Newly Synthesized Isoxazole of Vanillin Analogues

• Authors: Krushnakumar Karangiya , Jatin Upadhyay
• Languages of publication: EN

Abstracts

EN

Several 3-(Aryl)-5-[4-(2,4-dichloro-benzyloxy)-3-methoxy-phenyl]-isoxazole derivatives (1a-1h) have been synthesized by refluxing various 3-Methoxy-4-(2,4-dichlorophenylmethoxy) chalcones with hydroxylamine hydrochloride and catalytic amount of acetic acid results good to moderate yield. 3-Methoxy-4-(2,4-dichlorophenylmethoxy) chalcones were synthesized by constant stirring of 3-Methoxy-4-(2,4-dichlorophenylmethoxy)benzaldehyde with different substituted acetophenones. The analytical and physical data of all the synthesized compounds (1a-1h) were observed and reported. The structures of each newly synthesized isoxazole derivative have been characterized by various methods like Elemental analysis, Infrared spectroscopy, 1H-NMR spectroscopy, and Mass spectroscopy. Furthermore, each compound was screened for its in-vitro antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal towards fungi Aspergillus niger (A. niger) and Candida albicans (C. albicans) with the concentration of 40μg/ml and data was collected.

Keywords

EN

Anti-microbial; Chalcone; Heterocycle; Isoxazole; Vanillin

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2023
• Volume: 50
• Pages: 110-120

Contributors

author

Krushnakumar Karangiya

• Bahauddin Science College, College Road, Junagadh – 362001, Gujarat, India

author

Jatin Upadhyay

• M V M Science and Home Science College, Rajkot – 360001, Gujarat, India

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• Document Type: article