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Journal
2017 | 7 | 4 | 180-183
Article title

The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma

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EN
Abstracts
EN
Cutaneous and soft tissue involvement is a very rare manifestation of multiple myeloma. We are describing a woman with the huge multiple plasma cells infiltrations of the soft tissues and the skin of the right shoulder and the arm that had occurred 2.5 years after the diagnosis of multiple myeloma. In the case of the described patient there is a distinct correlation between the appearance of the nodular lesions in soft tissues and the underlying osteolytic changes found in the skeleton. We assumed that the fracture of the right humerus in the past was the beginning of the plasma cells dissemination in the adherent tissues. The skin changes in our patient appeared in the advanced stage of multiple myeloma. There was only transient improvement of cutaneous changes after the chemotherapy, despite the complete remission of the underlying disease in the bone marrow. Despite of the intensive treatment (chemotherapy, radiotherapy) the patient died 7 months after the first appearance of the skin changes.
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Journal
Year
Volume
7
Issue
4
Pages
180-183
Physical description
Contributors
  • Clinic of Hematology of the Holy Cross Centre in Kielce, Poland; The Faculty of Medicine and Health Science, Jan Kochanowski University Kielce, Poland
  • Clinic of Hematology of the Holy Cross Centre in Kielce, Poland
author
  • Clinic of Hematology of the Holy Cross Centre in Kielce, Poland
References
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  • 3. Requena L, Kutzner H, Palmedo G et al. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol 2003; 139: 475-486.
  • 4. Bayer-Garner IB, Smoller BR. The spectrum of cutaneous disease in multiple myeloma. J Am Acad Dermatol 2003; 48: 497-507.
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  • 9. Rosenblum MD, Bredeson CN, Chang CC, Rizzo JD. Subcutaneous plasmacytomas with tropism to sites of previous trauma in a multiple myeloma patient treated with an autologous bone marrow transplant. Am J Hematol 2003; 72: 274-277.
  • 10. Shpilberg O, Yaniv R, Levy Y et al. Huge cutaneous plasmacytomas complicating multiple myeloma. Clin Exp Dermatol 1994; 19: 324-326.
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  • 13. Patterson JW, Parsons JM, White RM et al. Cutaneous involvement of multiple myeloma and extramedullary plasmacytoma. J Am Acad Dermatol 1988; 19: 879-890.
  • 14. Patel K, Carrington PA, Bhatnagar S et al. IgD myeloma with multiple cutaneous plasmacytomas. Clin Lab Haematol 1998; 20: 53-55.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-68111952-f2c4-478a-b674-b8080fe03f55
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