Nephroprotective role of Potentilla reptans L. aqueous extract on paracetamol - induced kidney nephrotoxicity in male mice

• Authors: M. Muthulingam , C. Prabhahar , S. Senthilmurugan , K. Pugazhendy , P. Vijayan , M. Baranitharan
• Languages of publication: EN

Abstracts

EN

Nephroprotective effects (NPE) of simple Potentilla reptans - aqueous leaf extract (Pr-ALE) leaves on Paracetamol induced kidney poisonousness in wistar rats. Adult male wistar rats (weight range (WR): 200-220g) were divided into 6 groups (n=6). Paracetamol (PA) and Silymarin (SY) stayed managed intraperitoneally arranged the 5th day to rats in all groups but the normal control. Furthermore, a significant nephroprotective (NP) of the aqueous leaf extract (ALE) and oral dose of PA and SY. Pr-ALE did not mortality or significant changes in the body weight. Progression of nephrotoxicity (NT) induced by PA in rats was interfered by Pr-ALE managed, and these effects were correspond to those managed with SY. This is the first record on NPE of Pr against PA-induced NT.

Keywords

EN

Nephroprotective; Nephrotoxicity; Paracetamol; Potentilla reptans; Silymarin

Discipline

• ANIMAL_SCIENCES: ANIMAL SCIENCES

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2021
• Volume: 39
• Pages: 76-85

Contributors

author

M. Muthulingam

• Department of Zoology, Annamalai University, Annamalainagar - 608002, Tamil Nadu, India

author

C. Prabhahar

• Department of Zoology, Annamalai University, Annamalainagar - 608002, Tamil Nadu, India

author

S. Senthilmurugan

• Department of Zoology, Annamalai University, Annamalainagar - 608002, Tamil Nadu, India

author

K. Pugazhendy

• Department of Zoology, Annamalai University, Annamalainagar - 608002, Tamil Nadu, India

author

P. Vijayan

• Department of Zoology, Annamalai University, Annamalainagar - 608002, Tamil Nadu, India

author

M. Baranitharan

• Department of Zoology, Annamalai University, Annamalainagar - 608002, Tamil Nadu, India

References

• [1] Dubey S, Yadav C, Bajpeyee A, Singh MP. Effect of Pleurotus fossulatus aqueous extract on biochemical properties of liver and kidney in streptozotocin-induced diabetic rat. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 13 (2020) 3036-3046
• [2] Begum Q, Noori S, Mahboob T. Antioxidant effect of sodium selenite on thioacetamide-induced renal toxicity. Pakistan Journal of Biochemistry & Molecular Biology 44 (2011) 21-26
• [3] Silva FG. Chemical-induced nephropathy: a review of the renal tubule interstitial lesions in humans. Toxicologic Pathology 32 (2004) 71-84
• [4] Etoh T, Inoguchi T, Kakimoto M, Sonoda N, Kobayashi K, Kuroda J, Sumimoto H, Nawata H. Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of Streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia 46 (2003) 1428-1437
• [5] Rosita; Yuandani; Marianne. Nephroprotective activity of ethanol extract of Curcuma mangga Val. in paracetamol-induced male mice. Asian Journal of Pharmaceutical and Clinical Research 11 (2018) 126-128
• [6] Case J, Khan S, Khalid R, Khan A. Epidemiology of acute kidney injury in the intensive care unit. Critical Care Research Practice 479730 (2013).
• [7] Kohli HS, Bhaskaran MC, Muthukumar T, Thennarasu K, Sud K, Jha V, Gupta KL, Sakhuja V. Treatment-related acute renal failure in the elderly: a hospital-based prospective study. Nephrology Dialysis Transplantation 15 (2000) 212-17. https://doi.org/10.1093/ndt/15.2.212
• [8] Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S. Paracetamol: new vistas of an old drug. Fall-Winter 12 (2006) 250-75
• [9] Sheen C, Dillon J, Bateman D, Simpson K, Macdonald T. Paracetamol toxicity: epidemiology, preventionand costs to the health-care system. Journal of the Association of Physicians 95 (2002) 609-19
• [10] Marsha Ford, Kathleen A Delaney, Louis Ling, Timothy Erickson. Clinical toxicology. 1st edition. Philadelphia 7WB Saunders (2000) 757-67.
• [11] Jones AF, Vale JA. Paracetamol poisoning and thekidney. Journal of Clinical Pharmacology and Therapeutics 18 (1993) 5-8
• [12] Sarumathy, K. A protective effect of Caesalpinia sappan on acetaminophen induced nephrotoxicity and oxidativestress in male albino rats. IJPI's Journal of Pharmacology and Toxicology 1 (2011) 2
• [13] Ajayi, J. B., A. O. Agbeyangi, A. Daniel, I. Omobolaji, H. O. Mogaji, Clinical Manifestations of Plasmodium berghei ANKA Infection in Juvenile Mice: A Short Case Report. World News of Natural Sciences 14 (2017) 90-96
• [14] Whelton A, Hamilton CW. Nonsteroidal anti-inflammatory drugs: Effects on kidney function. The Journal of Clinical Pharmacology 31 (1991) 588-98
• [15] Palani S, Raja S, Kumar RP, Jayakumar S, Kumar BS. Therapeutic efficacy of Pimpinella tirupatiensis (Apiaceae) on acetaminophen induced nephrotoxicity and oxidative stress in male albino rats. International Journal of PharmTech Research 1 (2009) 925-934
• [16] Montilla P, Barcos M, Munoz M, Bujalance C, Munoz-Castaneda JR, Tunez I. Red wine prevents brain oxidative stress and nephropathy in streptozotocin-induced diabetic rats. Journal of Biochemistry and Molecular Biology Research 38 (2005) 539-544
• [17] Mansour HH, Hafez HF, Fahmy NM. Silymarin modulates Cisplatin-induced oxidative stress and hepatotoxicityin rats. Journal of Biochemistry and Molecular Biology Research 39 (2006) 656-661
• [18] El-Beshbishy, H.A. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. Journal of Biochemistry and Molecular Biology Research 38 (2005) 300-306
• [19] Vermeulen PJ, Anten NPR, Schieving F, Werger MJA, During HJ. Height convergence in response to neighbor growth: genotypic differences in the stoloniferous plant Potentilla reptans. New Phytologist 177 (2008) 688-697
• [20] Tomovic M, Cupara TSM, Popovic-Milenkovic MT, Ljujic BT, Kostic MJ, Jankovic SM. Antioxidant and anti-inflammatory activity of Potentilla reptans L. Acta Poloniae Pharmaceutica - Drug Research 72 (2015) 137-145
• [21] Watkins F, Pendry B, Sanchez-Medina A, Corcoran O. Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England. Journal of Ethnopharmacology 144 (2012) 408-415
• [22] Alshawsh MA, Abdulla MA, Ismail S, Amin ZA. Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Evidence −Based Complementary and Alternative Medicine 103039 (2011) 6
• [23] Finn W, Porter G. Urinary biomarkers and nephrotoxicity. Clinical Nephrotoxins. 2nd ed. Massachusetts: Kluwer Academic Publishers (2003) 621-55
• [24] Galley HF. Can acute renal failure be prevented? Journal of Royal College of Surgeons of Edinburgh 45 (2000) 44-50
• [25] Perazella MA. Drug-induced nephropathy: an update. Expert Opinion on Drug Safety 4 (2005) 689-06
• [26] Adeneye AA, Olagunju JA, Benebo AS, Elias SO, Adisa AO, Idowu BO, et al. Nephro protective effects of the aqueous root extract of Harungana madagascariensis (l.) in acute and repeated dose acetaminophen renal injured rats. International Journal of Applied in Natural Products 1 (2008) 6-14
• [27] Hafsat O. Alabere, Efe I. Lucky, A. O. Ogundare, Abeeb I. Akinwunmi, Titilope Y. Abimbola, Comparative Test of Physicochemical Parameters and Microbiological Quality of Different Brands of Paracetamol Tablets Sold in Nigeria. World Scientific News 141 (2020) 12-23
• [28] Schnellman RG. Toxic responses of the kidney. In: Casarett and Doull`S Toxicology. The Basic Science of Poisons. 6th ed. New York: McGraw- Hill Medical Publishing Division (2001) 86-7
• [29] Ray SD, Jena N. A hepatotoxic of acetaminophen modulates expression of bcl-xl, and bcl-x5 during apoptotic and necrotic cell death of mouse liver cells in vivo. Archives of Toxicology 73 (2000) 594-606
• [30] Lorz C, Justo P, Sanz AB, Egido J, Ortiz A. Role of Bcl-xL in paracetamol-induced tubular epithelial cell death. Kidney International 67 (2005) 14-8
• [31] Singh D, Kaur R, Chander V, Chopra K. Antioxidant in the prevention of renal disease. Journal of Medicinal Food 9 (2006) 443-50
• [32] Goodman LS, Gilman A. The pharmacological basis of therapeutics. 11th ed. USA: McGraw-Hill (2006) 729-30
• [33] Madinah Naggayi, Nozmo Mukiibi, Ezekiel Iliya. The protective effects of aqueous extract of Carica papaya seeds in paracetamol induced nephrotoxicity in male wistar rats. African Health Sciences 15 (2015) 598-604
• [34] Praba S. Attribute selection and imbalanced data for detection of chronic kidney disease. Journal of International Pharmaceutical Research 46 (2019) 597-604
• [35] Olagunju JA, Adeneye A, Bamidele SF, Bisuga NA, Ketiku AO, Adokiye B, Olufowobi OM, Adeoye AG, Alimi MA, Adeleke AG. Nephroprotective activities of the aqueous seed extract of Carica papaya Linn. in carbon tetrachloride induced renal injured Wistar rats: a dose-and time-dependent study. Biology and Medicine 1 (2009) 11-19
• [36] Sharma M, Pundir J, Vishwakarma P, Goel RK, Saini M, Saxena KK. Evaluation of nephroprotective activity of Tinospora cordifolia against gentamicin induced nephrotoxicity in albino rats: an experimental study. International Journal of Basic & Clinical Pharmacology 8 (2019) 1179-84
• [37] Devi PS, Shyamala DC. Protective effect of quercetin in cisplatin induced cell injury in the rat kidney. Indian Journal of Pharmacology 31 (1999) 422-6
• [38] Arunkumar PA, Viswanatha GL, Radheshyam N, Mukund H, Belliyappa MS. Science behind cisplatin-induced nephrotoxicity in humans: A clinical study. Asian Pacific Journal of Tropical Biomedicine 2 (2012) 640-4
• [39] Neeraj KG, Sharad M, Tejram S, Abhinav M, Suresh PV, Rajeev KT. Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide. Asian Pacific Journal of Tropical Biomedicine 2 (2011) 57-63

• Document Type: article