Recent developments in Neem (Azadirachta indica – A. Juss) derived antimicrobial constituents for control of human and plant diseases – a review
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Neem has immense biocontrol potential against a large number of pathogens causing various diseases in human beings and plants. The plant has maximum useful value in its leaves, bark,, flowers and fruits than any other tree species. These values include antiallergic, antidermatic, antifeedent, antifungal and anti-inflammatory properties. Due to the vast activities of neem, it has become extremely valuable in making our ecosystem a green treasure. Neem leaves have been demonstrated to exhibit immuno-modulatory, anti-inflammatory, antiulcer, antimalarial properties. Neem tree plant parts contain a promising pest control substance which has found effective use against economically important agricultural pests. Neem plant products are easy to process by village level industries on the micro scale level and use by resource poor farmers in crop protection resulting thereby in income generation. This plant also has antioxidant properties and free radical scavenging potential in its different extracted solvents. The present review highlights the properties of neem against the pathogens of living organisms for environmental protection.
- 1. Serrone P.D., Toniolo C., Nicoletti M. Neem (Azadirachta indica A. Juss) oil to tackle enteropathogenic Escherichia coli. BioMed Research International 2015; ID 343610, 10pp. (http://dx.doi.org/10.1155/2015/ /343610).
- 2. Girish K., Shankara B.S. Neem-A green treasure. Electron. J. Biol. 2008; 4(3): 102–111.
- 3. Shah J.S, Shah M.B., Goswami S.S., Santani D.D. Mechanism of action of antiulcer activity of bark extract of Manikara hexandra against experimentally induced gastric ulcer in rats. Phcog. Mag. 2006; 2: 40–45.
- 4. Natarajan V., Veugopal P.V., Menon T. Effect of Azadirachta indica (neem) on the growth pattern of dermatophytes. Indian J. Med. Microbiol. 2003; 21: 98–101.
- 5. Akula C., Akula A., Drew R. Somatic Embryogenesis in colonial neem (Azadirachta indica). A. Juss. J. Microbial. Res. 2013; 3: 162–166.
- 6. Trease G.E., Evans W.C. A Textbook of Pharmacognosy. (13th ed). Bailliere Tinall Ltd, London. 1989; 100–101.
- 7. Hugo S.B., Rusell A.D. Pharmaceutical Microbiology. Blackwell Scientific Publication 1983; 3: 105–125.
- 8. Silver O.A., Cabrita P., Diniz A., Gomes B. Antimicrobial activity of Guinea Bissau traditional remedies. J. Ethnopharmacol. 1997; 50: 55–59.
- 9. Khan A.M., Alam M.M., Ahmad R. Mechanism of the control of plant parasitic nematodes as a result of the application of oil cakes to the soil. Indian J. Nematol. 1974; 4: 93–96.
- 10. Mankau R., Das S. Effect of organic materials on nematode bionomics in citrus and root-knot nematode infested field soil. Indian J. Nematol. 1974; 4: 138–151.
- 11. Jayarajan R. Effect of neem and other plant product in the management of plant disease in India. In natural pesticides from the neem tree (Azadirachta indica A.Juss) and other tropical plants (Ed. Schmutter). Eschborn, GFR, Deutsche GTZ. 1987: 635–644.
- 12. Saxena R.C., Khan Z.R., Bajet N.B. Reduction of Tungro virus transmission by Nephotettix virescens (Homoptera; Cicadellidae) in neem cake treated rice seedlings. J. Econ. Entomol. 1987; 80: 1079–1082.
- 13. Tripathi R.K.P., Tripathi R.N. Reduction in bean common mosaic virus (BCMV) infectivity vis-à-vis crude leaf extract of some higher plants. Experimentia 1982; 38(3): 349.
- 14. El-Mahmood A.M., Ogbonna O.B., Raji M. The antibacterial activity of Azadirachta indica (neem) seeds extract against bacterial pathogens asso-ciated with eye and ear infection. J. Med. Plants. Res. 2010; 4(14): 1414–1421.
- 15. Jahan T., Begum Z.A., Sultana S. Effect of neem oil on some pathogenic bacteria. Bangladesh J. Pharmacol. 2007; 2: 71–72.
- 16. Thakurta P., Bhowmik P., Mukharjee S., Hajra T.K., Patra A., Bag P.K. Aantibacterial, antisecretory and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India. J. Ethnopharmacol. 2007; 111(3): 607–612.
- 17. Winee S.L., Charan A.A., Bind A. Antimicrobial activity Of methanolic and acetonic extracts of Azadirachta indica, Saraca asoca and Curcuma longa. Int. J. Med. Pharm. Sci. 2013; 3(2): 79–86.
- 18. Irshad S., Butt M., Younus H. In vitro antibacterial activity of two medicinal plants neem (Azadirachta indica) and peppermint. Int. R. J. Pharmaceuticals. 2011; 1(1): 9–14.
- 19. Ranganathan S.M., Thangam B.A.M., Raja S.M. Antidermatophytic activities of Azadirachta indica: an in vitro and in vivo studies. Indian J. Derm. 1996; 41(4): 113–117.
- 20. Rao B.S.N., Rao M.J. Antifungal activity of gedunin. Cur. Sci. 1999; 46: 714–716.
- 21. Plant N., Garg H.S., Madhusudanan K.P., Bhakuni D.S. Sulfurous compounds from Azadirachta indica leaves. Fitoterapia 1986; 57: 302–304.
- 22. Dua V.K., Nagpal B.N., Sharma V.R. Repellant action of neem cream against mosquitoes. Indian J. Malaria 1995; 32: 47–53.
- 23. Pillai N.R., Santhakumari G. Effect of nimbidin on acute and chronic gastro-duodenal ulcer models in experimental animals. Plant. Medica. 1984; 50: 143–146.
- 24. Paul R., Prasad M., Sah N.K. Anticancer biology of Azadirachta indica L (neem): a mini review. Cancer Biol. Ther. 2011; 12: 467–476.
- 25. Dohroo N.P., Gupta S.K. Neem in plant disease control. Agricultural Reviews. 1995; 16(3): 133–140.
- 26. Autade R.H., Saini S., Reddy P.G., Deorukhkar S.C. Effect of neem extract against opportunistic bacterial and fungal pathogens associated with AIDS. Int. J. Curr. Micro. App. Sci. 2015; 4(3): 988–999.
- 27. Alam M.M, Khan M.W., Saxena S.K. Inhibitory effect of culture filtrates of some rhizosphere fungi on okra on the mortality and larval hatch of certain plant parasitic nematodes. Indian J. Nematol. 1973; 3: 94–98.
- 28. De N., Ifeoma E. Antimicrobial effect of components of the bark extract of neem (Azadirachta indica: A. Juss). J. Technol. Dev. 2002; 8: 2328.
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