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2017 | 15 | 2 | 142–145
Article title

In postmenopausal women, some uterine leiomyosarcomas mimic a cystic degeneration of uterine myoma: two case reports and a literature review

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EN
Abstracts
EN
Uterine leiomyosarcoma is an uncommon malignancy accounting for approximately 1% of gynecologic oncology cases. Most uterine leiomyosarcomas occur in menopausal women and they are notorious for their aggressive character, early dissemination, and poor prognosis. It is difficult to accurately differentiate uterine leiomyosarcoma from leiomyomas, especially when leiomyomas undergo degenerative changes. We treated two menopausal women with a uterine mass showing cystic change. Clinical work-up included needle aspiration, sonography, computed tomography, and serum tumor markers to differentiate uterine leiomyosarcoma from leiomyoma. All results were negative for malignancy, but uterine leiomyosarcoma was ultimately diagnosed by pathological examination. Until an accurate preoperative diagnostic method is available, menopausal women diagnosed with a degenerating cystic uterine fibroid should be considered to have a malignancy intraoperatively in order to prevent tumor cells from intraperitoneal spreading.
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Year
Volume
15
Issue
2
Pages
142–145
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References
  • 1. D’Angelo E, Prat J: Uterine sarcomas: a review. Gynecol Oncol 2010; 116: 131–139.
  • 2. Nam JH, Park JY: Update on treatment of uterine sarcoma. Curr Opin Obstet Gynecol 2010; 22: 36–42.
  • 3. Perri T, Korach J, Sadetzki S et al.: Uterine leiomyosarcoma: does the primary surgical procedure matter? Int J Gynecol Cancer 2009; 19: 257–260.
  • 4. Koh W, Greer BE, Abu-Rustum NR et al.: Uterine sarcoma, version 1.2016: featured updates to the NCCN Guidelines. J Natl Compr Canc Netw 2015; 13: 1321–1331.
  • 5. Harry VN, Narayansingh GV, Parkin DE: Uterine leiomyosarcomas: a review of the diagnostic and therapeutic pitfalls. The Obstetrician & Gynaecologist 2007; 9: 88–94.
  • 6. Pritts EA, Parker WH, Brown J et al.: Outcome of occult uterine leiomyosarcoma after surgery for presumed uterine fibroids: a systematic review. J Minim Invasive Gynecol 2015; 22: 26–33.
  • 7. George S, Barysauskas C, Serrano C et al.: Retrospective cohort study evaluating the impact of intraperitoneal morcellation on outcomes of localized uterine leiomyosarcoma. Cancer 2014; 120: 3154–3158.
  • 8. Raine-Bennett T, Tucker LY, Zaritsky E et al.: Occult uterine sarcoma and leiomyosarcoma: incidence of and survival associated with morcellation. Obstet Gynecol 2016; 127: 29–39.
  • 9. Exacoustos C, Romanini ME, Amadio A et al.: Can gray-scale and color doppler sonography differentiate between uterine leiomyosarcoma and leiomyoma? J Clin Ultrasound 2007; 35: 449–457.
  • 10. Cho HY, Kim K, Kim YB et al.: Differential diagnosis between uterine sarcoma and leiomyoma using preoperative clinical characteristics. J Obstet Gynaecol Res 2016; 42: 313–318.
  • 11. Kawamura N, Ichimura T, Ito F et al.: Transcervical needle biopsy for the differential diagnosis between uterine sarcoma and leiomyoma. Cancer 2002; 94: 1713–1720.
  • 12. Goto A, Takeuchi S, Sugimura K et al.: Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus. Int J Gynecol Cancer 2002; 12: 354–361.
  • 13. Sato K, Yuasa N, Fujita M et al.: Clinical application of diffusionweighted imaging for preoperative differentiation between uterine leiomyoma and leiomyosarcoma. Am J Obstet Gynecol 2014; 210: 368.e1–368.e8.
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article
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YADDA identifier
bwmeta1.element.psjd-645c1106-c18a-4701-91dc-e307cac2d6d0
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