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2020 | 141 | 66-90
Article title

Synthesis, spectral correlation analysis and evaluation of antimicrobial activities of some (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-ones

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Abstracts
EN
In this work, an attempt was made to synthesized (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-one by cross-aldol condensation reaction of 5′-acetyl-2,4-dimethylthiazole with various substituted Benz aldehyde in the presence base (sodium hydroxide). The synthesized (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-one derivative was characterized by physical constants, UV, FT-IR, 1H-NMR & 13C-NMR spectral data. All the observed spectral data of substituted (E)-1-(2,4-dimethylthiazol-5-yl)-3-phenylprop-2-en-1-one compounds have been correlated with Hammett substituent constants(σ, σ+, σI & σR) and F and R parameters using single and multi-linear regression analyses and studied for their anti-microbial activities and compared with the standard drugs (Ciprofloxacin). Some compound of the series exhibited promising anti-microbial activity compared to standard drugs (Ciprofloxacin).
Year
Volume
141
Pages
66-90
Physical description
Contributors
  • Department of Chemistry, Sourashtra College, Madurai - 625 004, India
author
  • Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608 102, India
author
  • Department of Chemistry, Government Arts College, C-Mutlur, Chidambaram - 608 102, India
  • Department of Chemistry, Annai College of Engineering and Technology, Kumbakonam - 612 503, India
author
  • Department of Chemistry, Thiruvalluvar Arts and Science College, Kurinjipaddi - 607 302, India
author
  • Department of Chemistry, Thiruvalluvar Arts and Science College, Kurinjipaddi - 607 302, India
author
  • Department of Chemistry, Annamalai University, Annamalainagar - 608 002, India
author
  • Department of Chemistry, Annamalai University, Annamalainagar - 608 002, India
  • Department of Chemistry, Annamalai University, Annamalainagar - 608 002, India
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-6306de74-8efb-4a64-abcd-ac4dd41fd03a
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