MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE

• Authors: Maria Mucha , Iwona Michalak , Zbigniew Draczyński
• Languages of publication: EN

Abstracts

EN

In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to standard forms of drug delivery.
The presented results are concerned with the release of ibuprofen from dibutyrylchitin film. The obtained transdermal films were modified by applying a control layer to slow down the release process. The matrices were also modified by adding nanoclay (Nanofil 2). Dibutyrylchitin matrices were tested for swelling and release kinetics using UV-Vis spectrophotometer. The drug kinetics release was studied in phosphorus buffer of pH=5.5 at the temperature of 35˚C. Structural investigations of the obtained matrices were carried out by optical microscopy and FTIR spectrophotometry. An appropriate mathematical model was also fitted to the obtained experimental data

Keywords

EN

controlled release; dibutyrylchitin; ibuprofen; nanoclay; transdermal systems

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 139-147

Contributors

author

Maria Mucha

• Faculty of Process and Environmental Engineering, Lodz University of Technology

author

Iwona Michalak

• Faculty of Process and Environmental Engineering, Lodz University of Technology

author

Zbigniew Draczyński

• Faculty of Materials Technology and Textile Design, Lodz University of Technology

References

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• Document Type: article