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2013 | 18 | 18 | 139-147
Article title

MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE

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EN
Abstracts
EN
In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to standard forms of drug delivery.
The presented results are concerned with the release of ibuprofen from dibutyrylchitin film. The obtained transdermal films were modified by applying a control layer to slow down the release process. The matrices were also modified by adding nanoclay (Nanofil 2). Dibutyrylchitin matrices were tested for swelling and release kinetics using UV-Vis spectrophotometer. The drug kinetics release was studied in phosphorus buffer of pH=5.5 at the temperature of 35˚C. Structural investigations of the obtained matrices were carried out by optical microscopy and FTIR spectrophotometry. An appropriate mathematical model was also fitted to the obtained experimental data
Publisher

Year
Volume
18
Issue
18
Pages
139-147
Physical description
Contributors
author
  • Faculty of Process and Environmental Engineering, Lodz University of Technology
  • Faculty of Materials Technology and Textile Design, Lodz University of Technology
References
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  • [5] Draczyński Z.; (2011) Synthesis and Solubility Properties of Chitin Acetate/Butyrate Copolymers, Journal of Applied Polymer Science, Vol. 122, p. 175-182.
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  • [7] Mucha M., Michalak I., Balcerzak J.; (2009) The comparison of effectiveness of ibuprofen release from films of dibutyrylchitin and poly(lactic acid), Monograph, ‘’Progress on Chemistry an Application of Chitin and its Derivatives’, Polish Chitin Society, vol. XIV, ISSN 1896-5644, s. 157-165.
  • [8] Szosland L., Krucińska I., et.al.; (2001), Synthesis of dibutyrylchitin and preparation of a new textiles made from dibutyrylchitin and chitin for medical applications, Fibres and Text. East. Eur., Vol. 9, no 3, s. 54-57.
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  • [13] Mulye N.V., Turco S.J.; (1995) A simple model based on first order kinetics to explain release of highly water soluble drugs from porous dicalcium phosphate dehydrate matrices., Drug Dev. Ind. Pharm. Vol.21, 943-953.
  • [14] Ramukutty S., Ramachandran E.; (2012) Growth, spectral and thermal studies of ibuprofen crystals, Cryst. Res. Technol. Vol. 47, No.1, 31-38.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-61100629-db8d-4051-b827-4536691a868e
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