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2011 | 65 | 1-2 | 89–98
Article title

PSA ciągle najlepszy marker nowotworowy, modyfi kacje testu i nowe markery raka stercza

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Title variants
EN
PSA still the best cancer marker, PSA test modifi cations and new prostate cancer markers
Languages of publication
PL
Abstracts
EN
The prostate-specific antigen is considered to be the most eff ective, though far from ideal, tumor marker. The basic aim of its application is to diagnose and diff erentiate between cancer and benign prostatic hyperplasia. The value of markers in case of prostate cancer is of particular importance, because of the long-term asymptomatic development. And recently, these values have become even more signifi cant, since there has been an increasing tendency to suff er from the disease. Our study presents advantages and imperfections of the PSA test, its modifi cations (e.g. dynamic tests) introduced in order to increase the specificity and sensitivity of the test, and thus its reliability. Subsequently proenzymes and PSA precursor forms as well as the opportunities for their use in the diagnostics are described. The rest of the article is devoted to the description of new potential prostate cancer markers, the implementation of which is closely associated with the development of molecular biology techniques. Among them the most important are: new kallikreins (PSA is also the member of kallikreins family), EPCA-2, PCA3, AMACR, products of gene fusion and rearrangements, GSTP1 hypermethlation, free non-cellular DNA and some antibodies.
PL
Od wielu lat specyficzny antygen sterczowy (PSA) uważany jest za najlepszy, choć daleki od ideału marker nowotworowy. Podstawowy cel jego zastosowania to pomoc w rozpoznawaniu i różnicowaniu raka i łagodnego przerostu gruczołu krokowego. Wartość markerów nowotworowych w przypadku raka stercza jest szczególnie ważna wobec faktu wieloletniego bezobjawowego rozwoju tego nowotworu, a szczególnego znaczenia nabiera ona w ostatnich latach, gdy obserwujemy stale wzrastającą tendencję do zachorowań. W pracy przedstawiono zalety i wady testu PSA, jego modyfikacje (np. testy dynamiczne) wprowadzone w celu zwiększenia czułości i specyficzności oraz – co za tym idzie – wiarygodności testu. W dalszej kolejności opisano proenzymy oraz formy prekursorowe PSA i możliwości wykorzystania ich w diagnostyce. W drugiej części pracy opisano nowe, potencjalne markery raka stercza, których próby wprowadzenia wiążą się z rozwojem technik biologii molekularnej. Należy tu wymienić kolejne kalikreiny (PSA jest także przedstawicielem tej rodziny), EPCA-2, PCA3, AMACR, produkty rearanżacji i fuzji genów, hipermetylacja GSTP1, wolne DNA w surowicy krwi, przeciwciała i szereg innych o nieco mniejszym znaczeniu.
Discipline
Year
Volume
65
Issue
1-2
Pages
89–98
Physical description
References
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article
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